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A Paradigm Shift to Prevent and Treat Alzheimer s Disease

A Paradigm Shift to Prevent and Treat Alzheimer s Disease
  • Author : Howard Friel
  • Publsiher : Academic Press
  • Release : 18 July 2017
  • ISBN : 012812279X
  • Pages : 290 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKA Paradigm Shift to Prevent and Treat Alzheimer s Disease

Summary:
A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols


A Paradigm Shift to Prevent and Treat Alzheimer's Disease

A Paradigm Shift to Prevent and Treat Alzheimer's Disease
  • Author : Howard Friel,Sally A. Frautschy
  • Publisher : Academic Press
  • Release : 18 July 2017
GET THIS BOOKA Paradigm Shift to Prevent and Treat Alzheimer's Disease

A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and

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ABC's of Alzheimers Disease

ABC's of Alzheimers Disease
  • Author : Bruce Bauer
  • Publisher : Covenant Books, Inc.
  • Release : 23 May 2019
GET THIS BOOKABC's of Alzheimers Disease

ABCs of Alzheimer's Disease: a Shared Reality by Me and My Shadow is a story of Bruce and Ethel's Alzheimer's disease (AD) journey, along with a history of AD from autopsies to PET scan research, including technology and genetic discoveries. The book is a realistic, short, comprehensive, evidence-based, description of Alzheimer's disease (AD). It describes AD research, including clinical trials, a simplified understanding of the brain, and the experiences of patient/caregiver persistence and journey as well as hope for

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The End of Alzheimer's

The End of Alzheimer's
  • Author : Dale Bredesen
  • Publisher : Penguin
  • Release : 22 August 2017
GET THIS BOOKThe End of Alzheimer's

The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it

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Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 03 June 2017
GET THIS BOOKComprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches

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Developing Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release : 27 May 2016
GET THIS BOOKDeveloping Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the

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Oxford Textbook of Public Mental Health

Oxford Textbook of Public Mental Health
  • Author : Dinesh Bhugra,Kamaldeep Bhui,Samuel Yeung Shan Wong,Stephen E. Gilman
  • Publisher : Oxford University Press
  • Release : 13 September 2018
GET THIS BOOKOxford Textbook of Public Mental Health

Prevention of mental illness and mental health promotion have often been ignored in the past, both in undergraduate and postgraduate curricula. Recently, however, there has been a clear shift towards public mental health, as a result of increasing scientific evidence that both these actions have a serious potential to reduce the onset of illness and subsequent burden as a result of mental illness and related social, economic and political costs. A clear distinction between prevention of mental illness and mental

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Phytomedicine and Alzheimer’s Disease

Phytomedicine and Alzheimer’s Disease
  • Author : Atanu Bhattacharjee,Akula Ramakrishna,M. Obulesu
  • Publisher : CRC Press
  • Release : 26 October 2020
GET THIS BOOKPhytomedicine and Alzheimer’s Disease

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease.

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The Biology of Alzheimer Disease

The Biology of Alzheimer Disease
  • Author : Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
  • Publisher : Anonim
  • Release : 22 May 2022
GET THIS BOOKThe Biology of Alzheimer Disease

Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer Disease, is also an intense area of research.

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Evidence-based Clinical Practice Guideline for Deprescribing Cholinesterase Inhibitors and Memantine

Evidence-based Clinical Practice Guideline for Deprescribing Cholinesterase Inhibitors and Memantine
  • Author : E. Reeve,B. Farrell,W. Thompson,N. Herrmann,I. Sketris,P. Magin,L. Chenoweth,M. Gorman,L. Quirke,G. Bethune,F. Forbes,S. Hilmer
  • Publisher : Anonim
  • Release : 06 February 2018
GET THIS BOOKEvidence-based Clinical Practice Guideline for Deprescribing Cholinesterase Inhibitors and Memantine

The End of Alzheimer's Program

The End of Alzheimer's Program
  • Author : Dale Bredesen
  • Publisher : Penguin
  • Release : 18 August 2020
GET THIS BOOKThe End of Alzheimer's Program

The instant New York Times bestseller The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower. In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed,

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Neurology for the Non-Neurologist, An Issue of Medical Clinics of North America

Neurology for the Non-Neurologist, An Issue of Medical Clinics of North America
  • Author : Tracey A Milligan
  • Publisher : Elsevier Health Sciences
  • Release : 31 January 2019
GET THIS BOOKNeurology for the Non-Neurologist, An Issue of Medical Clinics of North America

This issue of Medical Clinics, Guest Edited by Dr. Tracey A. Milligan, is devoted to Neurology. Articles in this issue include: Diagnosis of Neurologic Disorders; Dementia: Diagnosis and Treatment; Cerebrovascular Disease: Primary and Secondary Prevention; Seizures and Epilepsy; Migraine; Multiple Sclerosis and Autoimmune Neurology: Autoimmune Disease of the Brain and Spinal Cord; Concussion Evaluation and Management; Parkinsonism and Tremor; Compression and Entrapment Neuropathies; Peripheral Neuropathies; Falls and Gait Disorders; Nonmigraine Headache and Facial Pain; and Examination of the Dizzy Patient.

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Tau oligomers

Tau oligomers
  • Author : Jesus Avila,Naruhiko Sahara
  • Publisher : Frontiers E-books
  • Release : 18 August 2014
GET THIS BOOKTau oligomers

Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested

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The Oxford Handbook of Neuronal Protein Synthesis

The Oxford Handbook of Neuronal Protein Synthesis
  • Author : Wayne S. Sossin
  • Publisher : Oxford University Press
  • Release : 15 April 2021
GET THIS BOOKThe Oxford Handbook of Neuronal Protein Synthesis

Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook

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