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Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel
  • Publsiher : Academic Press
  • Release : 10 March 2016
  • ISBN : 0128005106
  • Pages : 868 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAdenoviral Vectors for Gene Therapy

Summary:
Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials


Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel
  • Publisher : Academic Press
  • Release : 10 March 2016
GET THIS BOOKAdenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors

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Cancer Gene Therapy

Cancer Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher : Springer Science & Business Media
  • Release : 03 November 2007
GET THIS BOOKCancer Gene Therapy

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail

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Therapeutic Applications of Adenoviruses

Therapeutic Applications of Adenoviruses
  • Author : Philip Ng,Nicola Brunetti-Pierri
  • Publisher : CRC Press
  • Release : 12 December 2016
GET THIS BOOKTherapeutic Applications of Adenoviruses

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the

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A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
  • Author : Roland W. Herzog,Sergei Zolotukhin
  • Publisher : World Scientific
  • Release : 09 December 2021
GET THIS BOOKA Guide to Human Gene Therapy

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years

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Therapeutic Applications of Adenoviruses

Therapeutic Applications of Adenoviruses
  • Author : Philip Ng,Nicola Brunetti-Pierri
  • Publisher : CRC Press
  • Release : 12 December 2016
GET THIS BOOKTherapeutic Applications of Adenoviruses

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the

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Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
  • Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
  • Publisher : Springer Science+Business Media
  • Release : 09 December 2021
GET THIS BOOKViral Vectors for Gene Therapy

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of

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Adeno-Associated Virus (AAV) Vectors in Gene Therapy

Adeno-Associated Virus (AAV) Vectors in Gene Therapy
  • Author : Kenneth I. Berns,Catherine Giraud
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKAdeno-Associated Virus (AAV) Vectors in Gene Therapy

Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this

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Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine
  • Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
  • Publisher : John Wiley & Sons
  • Release : 10 March 2017
GET THIS BOOKHolland-Frei Cancer Medicine

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage

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Viral Gene Therapy

Viral Gene Therapy
  • Author : Ke Xu
  • Publisher : BoD – Books on Demand
  • Release : 20 July 2011
GET THIS BOOKViral Gene Therapy

The development of technologies that allow targeting of specific cells has progressed substantially in recent years for several types of vectors, particularly viral vectors, which have been used in 70% of gene therapy clinical trials. Particular viruses have been selected as gene delivery vehicles because of their capacities to carry foreign genes and their ability to efficiently deliver these genes associated with efficient gene expression. This book is designed to present the most recent advances in viral gene therapy

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Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders
  • Author : Nicola Brunetti-Pierri
  • Publisher : Springer
  • Release : 22 May 2017
GET THIS BOOKSafety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers,

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Challenges in Delivery of Therapeutic Genomics and Proteomics

Challenges in Delivery of Therapeutic Genomics and Proteomics
  • Author : Ambikanandan Misra
  • Publisher : Elsevier
  • Release : 09 September 2010
GET THIS BOOKChallenges in Delivery of Therapeutic Genomics and Proteomics

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of

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Novel Gene Therapy Approaches

Novel Gene Therapy Approaches
  • Author : Ming Wei,David Good
  • Publisher : BoD – Books on Demand
  • Release : 13 February 2013
GET THIS BOOKNovel Gene Therapy Approaches

Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy,

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Gene Therapy Methods

Gene Therapy Methods
  • Author : M. Ian Phillips
  • Publisher : Academic Press
  • Release : 09 December 2021
GET THIS BOOKGene Therapy Methods

This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series. This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated

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