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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Author : Surendra Nimesh
  • Publsiher : Woodhead Publishing
  • Release : 04 April 2017
  • ISBN : 0081005636
  • Pages : 256 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAdvances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Summary:
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field


Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids
  • Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
  • Publisher : Woodhead Publishing
  • Release : 04 April 2017
GET THIS BOOKAdvances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles

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Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics
  • Author : Marco Filice,Jesús Ruiz-Cabello
  • Publisher : Elsevier
  • Release : 26 February 2019
GET THIS BOOKNucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book

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Advances and Challenges in Nanomedicine

Advances and Challenges in Nanomedicine
  • Author : Susan Hua,Sherry Y. Wu
  • Publisher : Frontiers Media SA
  • Release : 28 February 2019
GET THIS BOOKAdvances and Challenges in Nanomedicine

Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release : 27 August 2019
GET THIS BOOKNucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various

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Nanostructures for the Engineering of Cells, Tissues and Organs

Nanostructures for the Engineering of Cells, Tissues and Organs
  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release : 14 February 2018
GET THIS BOOKNanostructures for the Engineering of Cells, Tissues and Organs

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate

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Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy
  • Author : Ravin Narain
  • Publisher : Woodhead Publishing
  • Release : 09 January 2016
GET THIS BOOKPolymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials.

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Nanotechnology in Biology and Medicine

Nanotechnology in Biology and Medicine
  • Author : Pradipta Ranjan Rauta,Yugal Kishore Mohanta,Debasis Nayak
  • Publisher : CRC Press
  • Release : 10 October 2019
GET THIS BOOKNanotechnology in Biology and Medicine

Nanotechnology in biology and medicine: Research advancements & future perspectives is focused to provide an interdisciplinary, integrative overview on the developments made in nanotechnology till date along with the ongoing trends and the future prospects. It presents the basics, fundamental results/current applications and latest achievements on nanobiotechnological researches worldwide scientific era. One of the major goals of this book is to highlight the multifaceted issues on or surrounding of nanotechnology on the basis of case studies, academic and theoretical articles,

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Nanotechnology Applications for Cancer Chemotherapy

Nanotechnology Applications for Cancer Chemotherapy
  • Author : Sanyog Jain,Kaisar Raza,Ashish Kumar Agrawal,Ankur Vaidya
  • Publisher : Elsevier
  • Release : 30 September 2020
GET THIS BOOKNanotechnology Applications for Cancer Chemotherapy

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer

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Role of Plant Growth Promoting Microorganisms in Sustainable Agriculture and Nanotechnology

Role of Plant Growth Promoting Microorganisms in Sustainable Agriculture and Nanotechnology
  • Author : Ajay Kumar,Amit Kishore Singh,Krishna Kumar Choudhary
  • Publisher : Woodhead Publishing
  • Release : 20 June 2019
GET THIS BOOKRole of Plant Growth Promoting Microorganisms in Sustainable Agriculture and Nanotechnology

Role of Plant Growth Promoting Microorganisms in Sustainable Agriculture and Nanotechnology explores PGPMs (actinomycetes, bacteria, fungi and cyanobacteria) and their multidimensional roles in agriculture, including their increasing applications in sustainable agriculture. In addition to their traditional understanding and applications in agriculture, PGPMs are increasingly known as a source of nano-particles production that are gaining significant interest in their ability to provide more economically, environmentally friendly and safe technologies to crop growers. The book considers new concepts and current developments in

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Selected Papers from the 3rd European Congress on Imaging Infection and Inflammation

Selected Papers from the 3rd European Congress on Imaging Infection and Inflammation
  • Author : Alberto Signore,Luca Maria Sconfienza
  • Publisher : MDPI
  • Release : 07 December 2020
GET THIS BOOKSelected Papers from the 3rd European Congress on Imaging Infection and Inflammation

This Special Issue is a collection of selected papers from the 3rd European Congress on Imaging Infection and Inflammation (www.nuclearmedicinediscovery.org/events.asp) and results of consensus sessions by major experts in the field including Nuclear Medicine physicians, Radiologists, Clinicians and microbiologists. The Journal of Clinical Medicine (JCM) provides an opportunity to publish data that were presented and discussed at the meeting in Rome in December 2019. One of the extremely important missions of this meeting was to present the

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Proceedings of the 6th International Conference on Fundamental and Applied Sciences

Proceedings of the 6th International Conference on Fundamental and Applied Sciences
  • Author : Samsul Ariffin Abdul Karim,Mohd Fadhlullah Abd Shukur,Chong Fai Kait,Hassan Soleimani,Hamzah Sakidin
  • Publisher : Springer Nature
  • Release : 22 May 2022
GET THIS BOOKProceedings of the 6th International Conference on Fundamental and Applied Sciences

This book highlights latest advancement in Mathematics, Physics and Chemistry. With the theme of "Innovative Science towards Sustainability and Industrial Revolution 4.0", ICFAS 2020 brings together leading experts, scientific communities and industrialists working in the field of applied sciences and mathematics from all over the world to share the most recent developments and cutting-edge discoveries addressing sustainability and industrial revolution 4.0 in the field. The conference topics include green materials, molecular modelling, catalysis, nanodevices and nanosystems, smart materials applications, solar cells technology, computational

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Nano-Pharmacokinetics and Theranostics

Nano-Pharmacokinetics and Theranostics
  • Author : Nanasaheb D. Thorat,Nitesh Kumar
  • Publisher : Academic Press
  • Release : 28 July 2021
GET THIS BOOKNano-Pharmacokinetics and Theranostics

Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art

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Mixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization

Mixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization
  • Author : Catarina Melim,Ana Figueiras,Ivana Jarak,Ana Isabel Santos
  • Publisher : Bentham Science Publishers
  • Release : 09 March 2022
GET THIS BOOKMixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization

Osteosarcoma is a rare bone tumor that has a high incidence amongchildren and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to thepresence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basicscience behind the treatment of osteosarcoma along with experimental resultsfor a novel formulation that overcomes multidrug resistance, and therefore, mayserve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of

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