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AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
  • Author : Bibekanand Mallick
  • Publsiher : Academic Press
  • Release : 20 January 2019
  • ISBN : 0128156708
  • Pages : 387 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAGO Driven Non Coding RNAs

Summary:
The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy


AGO-Driven Non-Coding RNAs

AGO-Driven Non-Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release : 20 January 2019
GET THIS BOOKAGO-Driven Non-Coding RNAs

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years,


Transcriptional and Post-transcriptional Regulation

Transcriptional and Post-transcriptional Regulation
  • Author : Ghedira Kais
  • Publisher : BoD – Books on Demand
  • Release : 10 October 2018
GET THIS BOOKTranscriptional and Post-transcriptional Regulation

This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes


MicroRNAs in Cancer

MicroRNAs in Cancer
  • Author : César López-Camarillo,Laurence A. Marchat
  • Publisher : CRC Press
  • Release : 22 February 2013
GET THIS BOOKMicroRNAs in Cancer

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from


Regulatory RNAs

Regulatory RNAs
  • Author : Bibekanand Mallick,Zhumur Ghosh
  • Publisher : Springer Science & Business Media
  • Release : 01 February 2012
GET THIS BOOKRegulatory RNAs

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also


Human Biochemistry

Human Biochemistry
  • Author : Gerald Litwack
  • Publisher : Academic Press
  • Release : 09 November 2017
GET THIS BOOKHuman Biochemistry

Human Biochemistry includes clinical case studies and applications that are useful to medical, dentistry and pharmacy students. It enables users to practice for future careers as both clinicians and researchers. Offering immediate application of biochemical principles into clinical terms in an updated way, this book is the unparalleled textbook for medical biochemistry courses in medical, dental and pharmacy programs. Winner of a 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association Offers immediate application of


Transcription and Splicing

Transcription and Splicing
  • Author : B. D. Hames,David M. Glover,Professor of Molecular Genetics Department of Anatomy and Physiology David M Glover
  • Publisher : Oxford University Press
  • Release : 08 March 1988
GET THIS BOOKTranscription and Splicing

This book gives a co-ordinated review of our present knowledge of eukaryotic RNA synthesis.


Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release : 13 October 2017
GET THIS BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail


'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release : 20 March 2020
GET THIS BOOK'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology


Non-coding RNA and the Reproductive System

Non-coding RNA and the Reproductive System
  • Author : Dagmar Wilhelm,Pascal Bernard
  • Publisher : Springer
  • Release : 11 December 2015
GET THIS BOOKNon-coding RNA and the Reproductive System

This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus,


Managing Your Biological Data with Python

Managing Your Biological Data with Python
  • Author : Allegra Via,Kristian Rother,Anna Tramontano
  • Publisher : CRC Press
  • Release : 18 March 2014
GET THIS BOOKManaging Your Biological Data with Python

Take Control of Your Data and Use Python with ConfidenceRequiring no prior programming experience, Managing Your Biological Data with Python empowers biologists and other life scientists to work with biological data on their own using the Python language. The book teaches them not only how to program but also how to manage their data. It shows how


Non-coding RNAs and Cancer

Non-coding RNAs and Cancer
  • Author : Muller Fabbri
  • Publisher : Springer Science & Business Media
  • Release : 28 October 2013
GET THIS BOOKNon-coding RNAs and Cancer

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive


The Selfish Gene

The Selfish Gene
  • Author : Charles Simonyi Professor of the Public Understanding of Science Richard Dawkins,Richard Dawkins,David Dawkins,RICHARD AUTOR DAWKINS
  • Publisher : Oxford University Press, USA
  • Release : 08 March 1989
GET THIS BOOKThe Selfish Gene

An ethologist shows man to be a gene machine whose world is one of savage competition and deceit


Regulating with RNA in Bacteria and Archaea

Regulating with RNA in Bacteria and Archaea
  • Author : Gisela Storz,Kai Papenfort
  • Publisher : John Wiley & Sons
  • Release : 10 July 2020
GET THIS BOOKRegulating with RNA in Bacteria and Archaea

Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have


Autophagy: Biology and Diseases

Autophagy: Biology and Diseases
  • Author : Zheng-Hong Qin
  • Publisher : Springer Nature
  • Release : 27 November 2019
GET THIS BOOKAutophagy: Biology and Diseases

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development


Plant Long Non-Coding RNAs

Plant Long Non-Coding RNAs
  • Author : Julia A. Chekanova,Hsiao-Lin V. Wang
  • Publisher : Humana Press
  • Release : 20 April 2019
GET THIS BOOKPlant Long Non-Coding RNAs

This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and