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Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors
  • Author : Anonim
  • Publsiher : Academic Press
  • Release : 02 December 2012
  • ISBN : 012394791X
  • Pages : 488 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKOligomerization and Allosteric Modulation in G Protein Coupled Receptors

Summary:
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field


Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOKOligomerization and Allosteric Modulation in G-Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments


From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction,


Allosteric Receptor Modulation in Drug Targeting

Allosteric Receptor Modulation in Drug Targeting
  • Author : Norman G. Bowery
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKAllosteric Receptor Modulation in Drug Targeting

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors,


Protein Allostery in Drug Discovery

Protein Allostery in Drug Discovery
  • Author : Jian Zhang,Ruth Nussinov
  • Publisher : Springer Nature
  • Release : 09 November 2019
GET THIS BOOKProtein Allostery in Drug Discovery

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent



Allosterism in Drug Discovery

Allosterism in Drug Discovery
  • Author : Dario Doller
  • Publisher : Royal Society of Chemistry
  • Release : 24 November 2016
GET THIS BOOKAllosterism in Drug Discovery

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is


The Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors
  • Author : P. Jeffrey Conn,Jitendra Patel
  • Publisher : Springer Science & Business Media
  • Release : 09 March 2013
GET THIS BOOKThe Metabotropic Glutamate Receptors

The Metabotropic Glutamate Receptors offers state-of-the-art summaries and reviews of virtually everything known today about metabotropic glutamate receptors (mGluRs), including their molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles. Illuminating the overall role played by this crucial class of receptors in brain function, the book also pinpoints those areas in which there is the greatest continuing need for focused research. Because mGluRs have the potential for participating in virtually all known functions of the central nervous system (CNS),


GPCR Molecular Pharmacology and Drug Targeting

GPCR Molecular Pharmacology and Drug Targeting
  • Author : Annette Gilchrist
  • Publisher : John Wiley & Sons
  • Release : 10 December 2010
GET THIS BOOKGPCR Molecular Pharmacology and Drug Targeting

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and


GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release : 11 September 2019
GET THIS BOOKGPCRs

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible



Insights into Receptor Function and New Drug Development Targets

Insights into Receptor Function and New Drug Development Targets
  • Author : P. Michael Conn,Claude Kordon
  • Publisher : Springer Science & Business Media
  • Release : 28 September 2006
GET THIS BOOKInsights into Receptor Function and New Drug Development Targets

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.


Computational Methods for GPCR Drug Discovery

Computational Methods for GPCR Drug Discovery
  • Author : Alexander Heifetz
  • Publisher : Humana Press
  • Release : 30 August 2018
GET THIS BOOKComputational Methods for GPCR Drug Discovery

This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods


The Adenosine Receptors

The Adenosine Receptors
  • Author : Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi
  • Publisher : Humana Press
  • Release : 28 July 2018
GET THIS BOOKThe Adenosine Receptors

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and


Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases

Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases
  • Author : Senthilkumar Rajagopal,Murugavel Ponnusamy
  • Publisher : Springer
  • Release : 19 November 2018
GET THIS BOOKMetabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors.


Lipid Peroxidation

Lipid Peroxidation
  • Author : Angel Catalá
  • Publisher : Nova Science Publishers
  • Release : 03 March 2021
GET THIS BOOKLipid Peroxidation

This book presents an overview of lipid peroxidation: inhibition, effects and mechanisms. The topics analyzed, cover a broad spectrum of functions played by lipid peroxidation and presents new information in this area of research. The topics analyzed include: progress in the knowledge of lipid peroxidation, from the first evidences issued by Nicolas Theodore de Saussure in Paris 1804; fighting against lipid peroxidation: the unique story of docosahexaenoic acid in the brain; protective effects of melatonin and structurally-related molecules in reducing membrane