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An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Author : Tomas Koltai
  • Publsiher : Academic Press
  • Release : 16 January 2020
  • ISBN : 0128190604
  • Pages : 574 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH

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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs


An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 16 January 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve

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An Innovative Approach to Understanding and Treating Cancer

An Innovative Approach to Understanding and Treating Cancer
  • Author : Tomas Koltai,Stephan J Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 15 February 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer

The New pH-Centric Paradigm In Cancer Research: From Etiopathogenesis To New Therapeutic Avenues describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient, when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognised as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in

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Prostate Cancer Metabolism

Prostate Cancer Metabolism
  • Author : Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel
  • Publisher : Academic Press
  • Release : 25 June 2021
GET THIS BOOKProstate Cancer Metabolism

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact

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Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer
  • Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
  • Publisher : Elsevier
  • Release : 24 June 2021
GET THIS BOOKAdvanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells

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Receptor Tyrosine Kinases

Receptor Tyrosine Kinases
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 June 2020
GET THIS BOOKReceptor Tyrosine Kinases

Receptor Tyrosine Kinases, Volume 147 in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, their importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release are contributed by a

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Emerging Research and Treatments in Renal Cell Carcinoma

Emerging Research and Treatments in Renal Cell Carcinoma
  • Author : Robert Amato
  • Publisher : BoD – Books on Demand
  • Release : 03 February 2012
GET THIS BOOKEmerging Research and Treatments in Renal Cell Carcinoma

The field of renal cell cancer has undergone a significant resurgence. This book summarizes up-to-date research and innovative ideas for the future in this rapidly changing field, which encompasses medicine, surgery, radiation oncology, basic science, pathology, radiology, and supportive care. This book is aimed at the clinician or scientist who has an interest in renal cell cancer, whether they are academic or nonacademic. The book covers tumor biology, molecular biology, surgery techniques, radiation therapy, personal testimonies, and present and future

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Cancer Treatment

Cancer Treatment
  • Author : Letícia Rangel
  • Publisher : BoD – Books on Demand
  • Release : 09 May 2013
GET THIS BOOKCancer Treatment

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5:

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Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia
  • Author : Ajay Vora
  • Publisher : Springer
  • Release : 21 April 2017
GET THIS BOOKChildhood Acute Lymphoblastic Leukemia

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor

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Plant Flavonoids Against Metastasis: New Concepts for Cancer Treatment

Plant Flavonoids Against Metastasis: New Concepts for Cancer Treatment
  • Author : Katrin Sak
  • Publisher : Anonim
  • Release : 01 March 2021
GET THIS BOOKPlant Flavonoids Against Metastasis: New Concepts for Cancer Treatment

Cancer poses a major threat to human health and is one of the leading causes of death worldwide. Today, we know that metastasis, a multistep process whereby tumor cells spread from the site of origin to distant organs, is responsible for most cancer mortality. In fact, more than 90% of cancer-related deaths are attributed to tumor metastasis. Unfortunately, there are no therapies currently available to specifically target metastasis of any human cancer types, and patients with distant metastases ultimately die from

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Stem Cells and Biomaterials for Regenerative Medicine

Stem Cells and Biomaterials for Regenerative Medicine
  • Author : Marek J. Los,Andrzej Hudecki,Emilia Wiechec
  • Publisher : Academic Press
  • Release : 07 November 2018
GET THIS BOOKStem Cells and Biomaterials for Regenerative Medicine

Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem

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