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An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Author : Tomas Koltai
  • Publsiher : Academic Press
  • Release : 16 January 2020
  • ISBN : 0128190604
  • Pages : 574 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH

Summary:
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs


An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 16 January 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve





Cancer Treatment

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  • Author : Letícia Rangel
  • Publisher : BoD – Books on Demand
  • Release : 09 May 2013
GET THIS BOOKCancer Treatment

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5:



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  • Author : Alina Maria Holban,Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release : 12 July 2016
GET THIS BOOKNanoarchitectonics for Smart Delivery and Drug Targeting

Nanoarchitectonics for Smart Delivery and Drug Targeting is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area of nanotechnology which allows scientists to arrange nanoscale structural units, typically a group of atoms or molecules, in an intended configuration. This book assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting using nanoarchitectonics and discusses the advantages and disadvantages of each application. Provides a scholarly introduction


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  • Author : Lucie Laplane
  • Publisher : Harvard University Press
  • Release : 06 June 2016
GET THIS BOOKCancer Stem Cells

A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.



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  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 June 2020
GET THIS BOOKReceptor Tyrosine Kinases

Receptor Tyrosine Kinases, Volume 147 in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, their importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release are contributed by a




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  • Author : Tadhg P. Begley
  • Publisher : Wiley
  • Release : 03 February 2009
GET THIS BOOKWiley Encyclopedia of Chemical Biology, Volume 3

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and