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An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Author : Tomas Koltai
  • Publsiher : Academic Press
  • Release : 16 January 2020
  • ISBN : 0128190604
  • Pages : 574 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer Targeting pH

Summary:
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs


An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release : 16 January 2020
GET THIS BOOKAn Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve

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Prostate Cancer Metabolism

Prostate Cancer Metabolism
  • Author : Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel
  • Publisher : Academic Press
  • Release : 25 June 2021
GET THIS BOOKProstate Cancer Metabolism

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact

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Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 26 January 2022
GET THIS BOOKAntiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant

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Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics
  • Author : Kinam Park
  • Publisher : Woodhead Publishing
  • Release : 05 March 2020
GET THIS BOOKBiomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three

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Multi-Targeted Approach to Treatment of Cancer

Multi-Targeted Approach to Treatment of Cancer
  • Author : Varsha Gandhi,Kapil Mehta,Rajesh Grover,Sen Pathak,Bharat B. Aggarwal
  • Publisher : Springer
  • Release : 29 January 2015
GET THIS BOOKMulti-Targeted Approach to Treatment of Cancer

In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pathways. Genomics, proteomics, and metabolomics have revealed that dysregulation of dozens of genes and their products occur in any given cell type that ultimately leads to cancer. These discoveries are providing unprecedented opportunities to tackle cancer by

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Receptor Tyrosine Kinases

Receptor Tyrosine Kinases
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 June 2020
GET THIS BOOKReceptor Tyrosine Kinases

Receptor Tyrosine Kinases, Volume 147 in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, their importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release are contributed by a

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Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Author : Ammad Ahmad Farooqi,Muhammad Ismail
  • Publisher : Springer
  • Release : 29 March 2017
GET THIS BOOKMolecular Oncology: Underlying Mechanisms and Translational Advancements

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity,

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Emerging Research and Treatments in Renal Cell Carcinoma

Emerging Research and Treatments in Renal Cell Carcinoma
  • Author : Robert Amato
  • Publisher : BoD – Books on Demand
  • Release : 03 February 2012
GET THIS BOOKEmerging Research and Treatments in Renal Cell Carcinoma

The field of renal cell cancer has undergone a significant resurgence. This book summarizes up-to-date research and innovative ideas for the future in this rapidly changing field, which encompasses medicine, surgery, radiation oncology, basic science, pathology, radiology, and supportive care. This book is aimed at the clinician or scientist who has an interest in renal cell cancer, whether they are academic or nonacademic. The book covers tumor biology, molecular biology, surgery techniques, radiation therapy, personal testimonies, and present and future

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Innovative Approaches for Nanobiotechnology in Healthcare Systems

Innovative Approaches for Nanobiotechnology in Healthcare Systems
  • Author : Amna, Touseef,Hassan, M. Shamshi
  • Publisher : IGI Global
  • Release : 17 September 2021
GET THIS BOOKInnovative Approaches for Nanobiotechnology in Healthcare Systems

Innovative and fusion technologies have shown an incredible ability to improve various aspects of society, such as healthcare systems. Nanobiotechnology is one such technology that is being applied to medical equipment and treatment approaches. Many pharmaceutical and medical companies have begun to count on medical nanotechnology due to its abundant applications and practical uses. Innovative Approaches for Nanobiotechnology in Healthcare Systems is a pivotal reference source that provides insights into a comprehensive collection of novel techniques used for the development

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Phase I Cancer Clinical Trials

Phase I Cancer Clinical Trials
  • Author : Elizabeth A. Eisenhauer,Christopher Twelves,Marc Buyse
  • Publisher : Oxford University Press
  • Release : 20 March 2015
GET THIS BOOKPhase I Cancer Clinical Trials

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints

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Mining, Materials, and the Sustainable Development Goals (SDGs)

Mining, Materials, and the Sustainable Development Goals (SDGs)
  • Author : Christian Parra,Brandon Lewis,Saleem H. Ali
  • Publisher : CRC Press
  • Release : 14 October 2020
GET THIS BOOKMining, Materials, and the Sustainable Development Goals (SDGs)

Mining, Materials, and the Sustainable Development Goals (SDGs): 2030 and Beyond provides a systematic assessment of how the mining and materials sector contributes to the 17 sustainable development goals (SDGs) set forth by the United Nations in 2015. While the target date of 2030 is considered a benchmark for reaching these goals, the book looks beyond this date and considers a longer-term vision. FEATURES Written by a consortium of authors from developing and developed countries Offers coverage of environmental, economic, and social dimensions of

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Cancer Treatment

Cancer Treatment
  • Author : Letícia Rangel
  • Publisher : BoD – Books on Demand
  • Release : 09 May 2013
GET THIS BOOKCancer Treatment

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5:

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