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Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
  • Author : Eleftheria Zeggini
  • Publsiher : Academic Press
  • Release : 17 November 2010
  • ISBN : 9780123751430
  • Pages : 340 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAnalysis of Complex Disease Association Studies

Summary:
According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks


Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Academic Press
  • Release : 17 November 2010
GET THIS BOOKAnalysis of Complex Disease Association Studies

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease


Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : Jonathan L. Haines,Margaret A. Pericak-Vance
  • Publisher : John Wiley & Sons
  • Release : 05 May 2006
GET THIS BOOKGenetic Analysis of Complex Disease

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing



Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : Jonathan L. Haines,Margaret A. Pericak-Vance
  • Publisher : John Wiley & Sons
  • Release : 05 May 2006
GET THIS BOOKGenetic Analysis of Complex Disease

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing


Omic Association Studies with R and Bioconductor

Omic Association Studies with R and Bioconductor
  • Author : Juan R. González,Alejandro Cáceres
  • Publisher : CRC Press
  • Release : 14 June 2019
GET THIS BOOKOmic Association Studies with R and Bioconductor

After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers


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Applied Statistical Genetics with R
  • Author : Andrea S. Foulkes
  • Publisher : Springer Science & Business Media
  • Release : 28 April 2009
GET THIS BOOKApplied Statistical Genetics with R

Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.


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  • Publisher : John Wiley & Sons
  • Release : 09 July 2019
GET THIS BOOKHandbook of Statistical Genomics

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies,


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  • Author : Phuc Van Pham
  • Publisher : BoD – Books on Demand
  • Release : 05 April 2017
GET THIS BOOKBreast Cancer

Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as




Genome-wide Association Studies and Genomic Prediction

Genome-wide Association Studies and Genomic Prediction
  • Author : Cedric Gondro,Julius van der Werf,Ben J. Hayes
  • Publisher : Anonim
  • Release : 01 March 2021
GET THIS BOOKGenome-wide Association Studies and Genomic Prediction

"With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls


Rheumatoid Arthritis

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  • Author : Gary S. Firestein,Gabriel Stavros Panayi,Frank A. Wollheim
  • Publisher : Oxford University Press, USA
  • Release : 01 March 2021
GET THIS BOOKRheumatoid Arthritis

This book presents the cutting edge of developments in etiology, mechanisms of inflammation, disease manifestations and management of this common, crippling disease. Here is a new major volume on the subject of great importance in rheumatology - the first in-depth, multiauthor textbook on RAfor 15 years. Therapy for RA has traditionally been with non-steroid anti-inflammatory drugs, progressing to second-line drugs, but this has not been effective in preventing erosion of bone and symptoms. Rapid recent advances in knowledge have led to


Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine
  • Author : Sandosh Padmanabhan
  • Publisher : Academic Press
  • Release : 28 April 2014
GET THIS BOOKHandbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists,


An Introduction to Genetic Epidemiology

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  • Author : Lyle J. Palmer,George Davey Smith,Paul R. Burton
  • Publisher : Policy Press
  • Release : 31 May 2011
GET THIS BOOKAn Introduction to Genetic Epidemiology

Genetic epidemiology is a field that has acquired a central role in modern biomedical science. This book provides an introduction to genetic epidemiology that begins with a primer in human molecular genetics and then examines the standard methods in population genetics and genetic epidemiology


Genetics and Genomics of Eye Disease

Genetics and Genomics of Eye Disease
  • Author : Xiaoyi Raymond Gao
  • Publisher : Academic Press
  • Release : 12 September 2019
GET THIS BOOKGenetics and Genomics of Eye Disease

Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients,