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Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
  • Author : Eleftheria Zeggini
  • Publsiher : Academic Press
  • Release : 17 November 2010
  • ISBN : 9780123751430
  • Pages : 340 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAnalysis of Complex Disease Association Studies

Summary:
According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests Extensive list of references including links to tutorial websites Case studies and Tips and Tricks


Analysis of Complex Disease Association Studies

Analysis of Complex Disease Association Studies
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Academic Press
  • Release : 17 November 2010
GET THIS BOOKAnalysis of Complex Disease Association Studies

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease

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Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : Bill Scott,Marylyn Ritchie
  • Publisher : John Wiley & Sons
  • Release : 14 December 2021
GET THIS BOOKGenetic Analysis of Complex Disease

An up-to-date and complete treatment of the strategies, designs, and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Disease, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs, and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the

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Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : William K. Scott,Marylyn D. Ritchie
  • Publisher : John Wiley & Sons
  • Release : 11 November 2021
GET THIS BOOKGenetic Analysis of Complex Disease

Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common

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Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease
  • Author : Jonathan L. Haines,Margaret A. Pericak-Vance
  • Publisher : Wiley-Liss
  • Release : 05 May 2006
GET THIS BOOKGenetic Analysis of Complex Disease

Provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating

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JOINT ANALYSIS OF MULTIPLE PHENOTYPES IN ASSOCIATION STUDIES

JOINT ANALYSIS OF MULTIPLE PHENOTYPES IN ASSOCIATION STUDIES
  • Author : Anonim
  • Publisher : Anonim
  • Release : 18 May 2022
GET THIS BOOKJOINT ANALYSIS OF MULTIPLE PHENOTYPES IN ASSOCIATION STUDIES

Abstract : Genome-wide association studies (GWAS) have become a very effective research tool to identify genetic variants of underlying various complex diseases. In spite of the success of GWAS in identifying thousands of reproducible associations between genetic variants and complex disease, in general, the association between genetic variants and a single phenotype is usually weak. It is increasingly recognized that joint analysis of multiple phenotypes can be potentially more powerful than the univariate analysis, and can shed new light on underlying

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Genetics of Complex Disease

Genetics of Complex Disease
  • Author : Peter Donaldson,Ann Daly,Luca Ermini,Debra Bevitt
  • Publisher : Garland Science
  • Release : 25 August 2015
GET THIS BOOKGenetics of Complex Disease

Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest

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Linkage Disequilibrium and Association Mapping

Linkage Disequilibrium and Association Mapping
  • Author : Andrew Collins
  • Publisher : Springer Science & Business Media
  • Release : 18 May 2022
GET THIS BOOKLinkage Disequilibrium and Association Mapping

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In "Linkage Disequilibrium and Association Mapping: Analysis and Applications," scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology

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Assessing Rare Variation in Complex Traits

Assessing Rare Variation in Complex Traits
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Springer
  • Release : 13 August 2015
GET THIS BOOKAssessing Rare Variation in Complex Traits

This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of

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Genetic Association Studies: Background, Conduct, Analysis, Interpretation

Genetic Association Studies: Background, Conduct, Analysis, Interpretation
  • Author : Mehmet Tevfik Dorak
  • Publisher : Garland Science
  • Release : 28 September 2016
GET THIS BOOKGenetic Association Studies: Background, Conduct, Analysis, Interpretation

Genetic Association Studies is designed for students of public health, epidemiology, and the health sciecnes, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in

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Novel Approaches to the Analysis of Family Data in Genetic Epidemiology

Novel Approaches to the Analysis of Family Data in Genetic Epidemiology
  • Author : Xiangqing Sun,Jill S. Barnholtz-Sloan,Nathan Morris,Robert C. Elston
  • Publisher : Frontiers Media SA
  • Release : 17 August 2016
GET THIS BOOKNovel Approaches to the Analysis of Family Data in Genetic Epidemiology

Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable

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Computational Analyses of Complex Diseases at the Gene and Network Levels

Computational Analyses of Complex Diseases at the Gene and Network Levels
  • Author : Benjamin Christopher Lehne,King's College London. Guy's, King's and St. Thomas's School of Medicine. Division of Genetics & Molecular Medicine. Department of Medical & Molecular Genetics
  • Publisher : Anonim
  • Release : 18 May 2022
GET THIS BOOKComputational Analyses of Complex Diseases at the Gene and Network Levels

In this thesis I show how the integration of different bio-molecular datasets can generate a better understanding of complex disease and provide a mechanistic view of the underlying molecular processes. Genome-wide association studies (GWAS) proved successful in the identification of sequence variants associated with complex diseases. However, the necessity to apply stringent thresholds to ensure genome-wide significance suggests many associated variants might be missed. To incorporate variants with "suggestive" association signals I analysed GWAS data from the Wellcome Trust Case

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Applied Statistical Genetics with R

Applied Statistical Genetics with R
  • Author : Andrea S. Foulkes
  • Publisher : Springer Science & Business Media
  • Release : 28 April 2009
GET THIS BOOKApplied Statistical Genetics with R

Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

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Genes, brain, and emotions

Genes, brain, and emotions
  • Author : Andrei C. Miu,Judith R. Homberg,Klaus-Peter Lesch
  • Publisher : Oxford University Press
  • Release : 04 April 2019
GET THIS BOOKGenes, brain, and emotions

The study of emotions has rapidly expanded in recent decades, incorporating interdisciplinary research on the genetic underpinnings and neural mechanisms of emotion. This has involved a wide range of methods from as varied fields as behavioral genetics, molecular biology, and cognitive neuroscience, and has allowed researchers to start addressing complex multi-level questions such as: what is the role of genes in individual differences in emotions and emotional vulnerability to psychopathology, and what are the neural mechanisms through which genes and

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