Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research presents the detailed systematic anatomy of the rat, with a focus on toxicological needs. Most large works dealing with the laboratory rat provide a chapter on anatomy, but fall far short of the detailed account in this book which also focuses on the needs of toxicologists and others who use the rat as a laboratory animal. The book includes detailed guides on dissection methods and the location of

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The Laboratory Rat, Volume I: Biology and Diseases focuses on the use of rats in specific areas of research, ranging from dental research to toxicology. The first part of this book retraces the biomedical history of early events and personalities involved in the establishment of rats as a leading laboratory animal. The taxonomy, genetics and inbred strains of rats are also elaborated. The next chapters illustrate the hematology, clinical biochemistry, and anatomical and physiological features of the laboratory rat. This

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Comparative Anatomy and Histology: A Mouse and Human Atlas is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human

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Superior full-color photographs and illustrations distinguish this manual from others. This dissection guide and atlas provides carefully worded directions that allow students to learn basic mammalian anatomy through the use of a rat specimen. Great care has gone into the preparation of accurate and informative illustrations and the presentation of high-quality color photographs and photomicrographs. The text is clearly written, and dissection instructions are set apart from the text to assist students in the lab. Each chapter begins with a

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This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing

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The Illustrated Dictionary of Toxicologic Pathology and Safety Science provides descriptions of commonly used terms in toxicologic pathology with over 800 photomicrographs and illustrations to augment the written material. It also contains concise information, describing terms used in related areas such as anatomy, metabolism, drug development, and the allied fields of general toxicology. The definitions and descriptions were prepared and peer reviewed by editors and contributors who are known experts in toxicologic pathology, toxicology, and drug development.

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Introduction. Bone Biology. Anatomical Terminology. Skull. Dentition. Hyoid and Vertebrae. Thorax: Sternum and Ribs. Shoulder Girdle: Clavicle and Scapula. Arm: Humerus, Radius, Ulna. Hand: Carpals, Metacarpals, and Phalanges. Pelvic Girdle: Sacrum, Coccyx, and Os Coxae. Leg: Femur, Patella, Tibia, and Fibula. Foot: Tarsals, Metatarsals, and Phalanges. Recovery, Preparation, and Curation of Skeletal Remains. Analysis and Reporting of Skeletal Remains. Ethics in Osteology. Assessment of Age, Sex, Stature, Ancestry, and Identity. Osteological and Dental Pathology. Postmortem Skeletal Modification. The Biology of

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For many years, laboratory dogs have served as important animal models for biomedical research that has advanced human health. Conducted at the request of the U.S. Department of Veterans Affairs (VA), this report assesses whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA's mission. The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends

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Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a

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The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is

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Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and

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This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area

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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane

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