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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders,

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release : 20 June 2017
GET THIS BOOKAnimal Models for the Study of Human Disease

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Judith Axler Turner
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support for discipline-specific studies and cross-species resources. This article tracks LAMHDI, the initiative to Link Animal Models to Human DIsease (www.lamhdi.org), which brings together data about five species: flies,

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Daniel Butzke,Barbara Grune,Josephine Kugler,Michael Oelgeschläger,Andrea Seiler,Dana Sittner,Manfred Liebsch,Andreas Luch
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

The first years of the 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidence-based assessment of preclinical models, probing their true value in predicting clinical outcomes of human diseases. Likewise, several new approaches, e.g., stem cell-based, diseases-in-a-dish and organs-on-a-chip and lab-on-a-chip technologies have revitalized the domain of alternatives to animal experimentation. In our review, we portray

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Robert H. Miller,Sharyl Fyffe-Maricich,Andrew V. Caprariello
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

The most common demyelinating disease of the central nervous system (CNS) in the young adult population is multiple sclerosis (MS). MS is characterized by the focal loss of myelin sheaths in the brain and in the spinal cord of patients that is correlated with elevated activity of the immune system directed toward CNS antigens including myelin. The progression of MS is highly variable, but in many cases, it is characterized by a series of relapsing and remitting attacks that slowly

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Yoichi Gondo
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available. Newly developed tools of high-throughput identification of novel mutations and site-directed mutagenesis, or gene targeting, in the mouse genome have caused forward and reverse genetics, respectively, to rapidly expand during the last two decades. Worldwide efforts including a variety of international consortiums have been producing many useful mutant mouse strains for functional genomics to elucidate the mechanisms behind

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Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
  • Author : Bartholomew Ibeh
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2018
GET THIS BOOKExperimental Animal Models of Human Diseases

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Joachim Wistuba,Steffi Werler,Lars Lewejohann
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Klinefelter syndrome (KS) is a frequent (0.2%) sex chromosomal disorder in males presenting with a 47,XXY karyotype. This condition is associated with infertility, hypogonadism, and metabolic and cognitive impairments. As experimental research is restrictive in patients, animal models for KS are needed to explore its molecular and genetic basis. Supernumerary X chromosomes due to meiotic nondisjunctions sporadically also occur in males of other mammalian species and provoke the same or at least some of the features observed in patients. However, as

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Kristine Coleman,James L. Weed,Steven J. Schapiro
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Environmental enrichment is an integral part of animal care practices. Enrichment generally refers to items we provide to the animals to support their behavioral needs. It provides a way to functionally simulate the natural environment of captive animals, in an effort to increase opportunities for the expression of species-specific behaviors and decrease the occurrence of abnormal behaviors. Further, enrichment can also be a tool in the study of basic science questions, such as how environmental factors may affect disease etiology

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lucas M. Chaible,Denise Kinoshita,Marcus A. Finzi Corat,Maria L. Zaidan Dagli
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Genetically modified animals were created about 30 years ago, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, such as transgenic, knockout conditional knockout, and knockin animals, and the general techniques on how to obtain them are described. In addition, the available genetically modified models for genetic diseases, multifactorial and polygenic (complex) disorders, neurodegenerative, inflammatory diseases, besides cancer models, are presented. The aim of the chapter is to help investigators to find out

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Charles W. Schindler,Steven R. Goldberg
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Reward behavior represents a subset of conditioning procedures that have been developed by psychologists to study learning in animals. In particular, rewarded behavior involves an instrumental response that is maintained by a reinforcer. The procedures that have been developed cover a broad spectrum of behaviors, from simple running in a straight alley to very complex operant schedules of reinforcement that can require multiple responses over long periods of time. Many species of animal have also been trained on these procedures.

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Jerrold Tannenbaum
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying these fundamental principles in the design and implementation of animal research projects. The chapter highlights several important ethical issues regarding which the biomedical research community has expressed lack of clarity

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Mouse Cell Culture

Mouse Cell Culture
  • Author : Ivan Bertoncello
  • Publisher : Humana Press
  • Release : 20 February 2019
GET THIS BOOKMouse Cell Culture

This volume describes cell culture protocols for the maintenance, propagation, manipulation, and analysis of primary explanted cells from various mouse organ systems. After introductory chapters that examine the applicability of mouse models as a discovery tool and describe critical factors and variables that influence cell culture endpoints, protocol chapters explore cell culture methodologies for specific mouse cell types and lineages. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, comprehensive

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Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : David Feifel,Paul D. Shilling
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals. Furthermore, limited current understanding of the etiology and pathophysiology underlying the clinical features of this disorder greatly hinders the ability to develop valid models based on those aspects. To circumvent these issues, investigators have attempted to recreate the leading candidate biochemical, neuroanatomical, and genetic abnormalities for this disorder in animals using pharmacological, developmental,

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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
  • Publisher : National Academies Press
  • Release : 29 June 2018
GET THIS BOOKAdvancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed

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