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Annotating New Genes

Annotating New Genes
  • Author : Shizuka Uchida
  • Publsiher : Elsevier
  • Release : 06 August 2012
  • ISBN : 1908818123
  • Pages : 196 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKAnnotating New Genes

Summary:
In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented. Focuses not only on screening but also on biological validations Provides details of databases and software (web interface) products for biologists with minimal computation skills Offers a step-by-step outline of the procedure involved


Annotating New Genes

Annotating New Genes
  • Author : Shizuka Uchida
  • Publisher : Elsevier
  • Release : 06 August 2012
GET THIS BOOKAnnotating New Genes

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases

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Gene Prediction

Gene Prediction
  • Author : Martin Kollmar
  • Publisher : Humana Press
  • Release : 19 May 2019
GET THIS BOOKGene Prediction

This volume introduces software used for gene prediction with focus on eukaryotic genomes. The chapters in this book describe software and web server usage as applied in common use-cases, and explain ways to simplify re-annotation of long available genome assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary computational requirements, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough,

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Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics
  • Author : Jonathan Pevsner
  • Publisher : John Wiley & Sons
  • Release : 04 March 2005
GET THIS BOOKBioinformatics and Functional Genomics

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key

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Sequence — Evolution — Function

Sequence — Evolution — Function
  • Author : Eugene V. Koonin,Michael Galperin
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKSequence — Evolution — Function

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the

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The Gene Ontology Handbook

The Gene Ontology Handbook
  • Author : Christophe Dessimoz,Nives Skunca
  • Publisher : Anonim
  • Release : 08 October 2020
GET THIS BOOKThe Gene Ontology Handbook

This book provides a practical and self-contained overview of the Gene Ontology (GO), the leading project to organize biological knowledge on genes and their products across genomic resources. Written for biologists and bioinformaticians, it covers the state-of-the-art of how GO annotations are made, how they are evaluated, and what sort of analyses can and cannot be done with the GO. In the spirit of the Methods in Molecular Biology book series, there is an emphasis throughout the chapters on providing

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Assessing Rare Variation in Complex Traits

Assessing Rare Variation in Complex Traits
  • Author : Eleftheria Zeggini,Andrew Morris
  • Publisher : Springer
  • Release : 13 August 2015
GET THIS BOOKAssessing Rare Variation in Complex Traits

This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of

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An Integrated Approach to Enhancing Functional Annotation of Sequences for Data Analysis of a Transcriptome

Given the ever increasing quantity of sequence data, functional annotation of new gene sequences persists as being a significant challenge for bioinformatics. This is a particular problem for transcriptomics studies in crop plants where large genomes and evolutionarily distant model organisms, means that identifying the function of a given gene used on a microarray, is often a non-trivial task. Information pertinent to gene annotations is spread across technically and semantically heterogeneous biological databases. Combining and exploiting these data in a

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Next Generation Sequencing

Next Generation Sequencing
  • Author : Jerzy Kulski
  • Publisher : BoD – Books on Demand
  • Release : 14 January 2016
GET THIS BOOKNext Generation Sequencing

Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and

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Modern Biocatalysis

Modern Biocatalysis
  • Author : Gavin Williams,Mélanie Hall
  • Publisher : Royal Society of Chemistry
  • Release : 31 May 2018
GET THIS BOOKModern Biocatalysis

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics

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Advances in Animal Genomics

Advances in Animal Genomics
  • Author : Sukanta Mondal,Ram Lakhan Singh
  • Publisher : Academic Press
  • Release : 25 November 2020
GET THIS BOOKAdvances in Animal Genomics

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics

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Concepts and Techniques in Genomics and Proteomics

Concepts and Techniques in Genomics and Proteomics
  • Author : N Saraswathy,P Ramalingam
  • Publisher : Elsevier
  • Release : 01 July 2011
GET THIS BOOKConcepts and Techniques in Genomics and Proteomics

Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to

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Bioinformatics for Beginners

Bioinformatics for Beginners
  • Author : Supratim Choudhuri
  • Publisher : Elsevier
  • Release : 09 May 2014
GET THIS BOOKBioinformatics for Beginners

Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options.

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The Yeast Two-hybrid System

The Yeast Two-hybrid System
  • Author : Paul L. Bartel,Stanley Fields
  • Publisher : Anonim
  • Release : 26 June 1997
GET THIS BOOKThe Yeast Two-hybrid System

This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and

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Handbook of Statistical Genomics

Handbook of Statistical Genomics
  • Author : David J. Balding,Ida Moltke,John Marioni
  • Publisher : John Wiley & Sons
  • Release : 09 July 2019
GET THIS BOOKHandbook of Statistical Genomics

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies,

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