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Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Approaches to the Purification  Analysis and Characterization of Antibody Based Therapeutics
  • Author : Allan Matte
  • Publsiher : Elsevier
  • Release : 07 September 2020
  • ISBN : 0081030193
  • Pages : 222 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKApproaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Summary:
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography


Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
  • Author : Allan Matte
  • Publisher : Elsevier
  • Release : 07 September 2020
GET THIS BOOKApproaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in

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Analytical Characterization of Biotherapeutics

Analytical Characterization of Biotherapeutics
  • Author : Jennie R. Lill,Wendy Sandoval
  • Publisher : John Wiley & Sons
  • Release : 14 August 2017
GET THIS BOOKAnalytical Characterization of Biotherapeutics

The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting

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Capillary Gel Electrophoresis

Capillary Gel Electrophoresis
  • Author : Andras Guttman,László Hajba
  • Publisher : Newnes
  • Release : 04 December 2021
GET THIS BOOKCapillary Gel Electrophoresis

Capillary Gel Electrophoresis and Related Microseparation Techniques covers all theoretical and practical aspects of capillary gel electrophoresis. It also provides an excellent overview of the key application areas of nucleic acid, protein and complex carbohydrate analysis, affinity-based methodologies, micropreparative aspects and related microseparation methods. It not only gives readers a better understanding of how to utilize this technology, but also provides insights into how to determine which method will provide the best technical solutions to particular problems. This book can

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Immunological Approaches to the Diagnosis and Therapy of Breast Cancer

Immunological Approaches to the Diagnosis and Therapy of Breast Cancer
  • Author : G.P. Talwar
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKImmunological Approaches to the Diagnosis and Therapy of Breast Cancer

Once again we have gathered to discover and evaluate advances made in our ability to understand. diagnose and possibly treat breast cancer with the new reagents provided by monoclonal antibody techniques. In the last two years since our first International Workshop on Monoclonal Antibodies and Breast Cancer there has been an enormous surge in the number and quality of applications for these new reagents. Solid achievements have been made in identification and quantitation of estrogen and progesterone receptors. in histopathological

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Analysis of Aggregates and Particles in Protein Pharmaceuticals

Analysis of Aggregates and Particles in Protein Pharmaceuticals
  • Author : Hanns-Christian Mahler,Wim Jiskoot
  • Publisher : John Wiley & Sons
  • Release : 20 December 2011
GET THIS BOOKAnalysis of Aggregates and Particles in Protein Pharmaceuticals

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

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Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
  • Author : Uwe Gottschalk
  • Publisher : John Wiley & Sons
  • Release : 03 April 2017
GET THIS BOOKProcess Scale Purification of Antibodies

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes

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Antibody Drug Discovery

Antibody Drug Discovery
  • Author : Clive R. Wood
  • Publisher : World Scientific
  • Release : 16 May 2022
GET THIS BOOKAntibody Drug Discovery

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to

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Therapeutic Fc-Fusion Proteins

Therapeutic Fc-Fusion Proteins
  • Author : Steven M. Chamow,Thomas Ryll,Henry B. Lowman,Deborah Farson
  • Publisher : John Wiley & Sons
  • Release : 18 December 2013
GET THIS BOOKTherapeutic Fc-Fusion Proteins

Edited by three pioneers in the field, each with longstanding experience in the biotech industry, and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion proteins as therapeutics for human disease: from choosing the right molecular design, to pre-clinical characterization of the purified product, through to batch optimization and quality control for large-scale cGMP production. The whole of the second part is devoted to case studies of Fc-fusion

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Monoclonal Antibody Production

Monoclonal Antibody Production
  • Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
  • Publisher : National Academies Press
  • Release : 06 June 1999
GET THIS BOOKMonoclonal Antibody Production

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The

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Development of Antibody-Based Therapeutics

Development of Antibody-Based Therapeutics
  • Author : Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
  • Publisher : Springer Science & Business Media
  • Release : 24 April 2012
GET THIS BOOKDevelopment of Antibody-Based Therapeutics

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans

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Handbook of HPLC

Handbook of HPLC
  • Author : Danilo Corradini,Elena Eksteen (Katz),Roy Eksteen,Peter Schoenmakers,Neil Miller
  • Publisher : CRC Press
  • Release : 03 January 2011
GET THIS BOOKHandbook of HPLC

Delineating its usage in separation, purification and detection processes across a variety of disciplines, from industry to applied research, this work discusses the principles, techniques and instrumentation involving HPLC within a detailed framework. Over 100 tables present previously scattered experimental data.

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Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Gunnar Houen
  • Publisher : Humana
  • Release : 28 July 2021
GET THIS BOOKTherapeutic Antibodies

This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their

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Protein and Peptide Mass Spectrometry in Drug Discovery

Protein and Peptide Mass Spectrometry in Drug Discovery
  • Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
  • Publisher : John Wiley & Sons
  • Release : 26 September 2011
GET THIS BOOKProtein and Peptide Mass Spectrometry in Drug Discovery

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry

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FDA's Drug Review Process and the Package Label

FDA's Drug Review Process and the Package Label
  • Author : Tom Brody
  • Publisher : Academic Press
  • Release : 13 December 2017
GET THIS BOOKFDA's Drug Review Process and the Package Label

FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data

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