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Bioreactor Modeling

Bioreactor Modeling
  • Author : Jerome Morchain
  • Publsiher : Elsevier
  • Release : 06 October 2017
  • ISBN : 0081011660
  • Pages : 218 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKBioreactor Modeling

Summary:
Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response


Bioreactor Modeling

Bioreactor Modeling
  • Author : Jerome Morchain
  • Publisher : Elsevier
  • Release : 06 October 2017
GET THIS BOOKBioreactor Modeling

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand,

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Advanced Methods and Mathematical Modeling of Biofilm

Advanced Methods and Mathematical Modeling of Biofilm
  • Author : Mojtaba Aghajani Delavar,Junye Wang
  • Publisher : Academic Press
  • Release : 27 May 2022
GET THIS BOOKAdvanced Methods and Mathematical Modeling of Biofilm

Advanced Mathematical Modelling of Biofilms and its Applications covers the concepts and fundamentals of biofilms, including sections on numerical discrete and numerical continuum models and different biofilms methods, e.g., the lattice Boltzmann method (LBM) and cellular automata (CA) and integrated LBM and individual-based model (iBM). Other sections focus on design, problem-solving and state-of-the-art modelling methods. Addressing the needs to upgrade and update information and knowledge for students, researchers and engineers on biofilms in health care, medicine, food, aquaculture and

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Computational Modeling in Biomechanics

Computational Modeling in Biomechanics
  • Author : Suvranu De,Farshid Guilak,Mohammad Mofrad
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKComputational Modeling in Biomechanics

Availability of advanced computational technology has fundamentally altered the investigative paradigm in the field of biomechanics. Armed with sophisticated computational tools, researchers are seeking answers to fundamental questions by exploring complex biomechanical phenomena at the molecular, cellular, tissue and organ levels. The computational armamentarium includes such diverse tools as the ab initio quantum mechanical and molecular dynamics methods at the atomistic scales and the finite element, boundary element, meshfree as well as immersed boundary and lattice-Boltzmann methods at the continuum

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Bioreactor System Design

Bioreactor System Design
  • Author : Juan A. Asenjo
  • Publisher : CRC Press
  • Release : 17 November 1994
GET THIS BOOKBioreactor System Design

Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and

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Predictive Modeling of Pharmaceutical Unit Operations

Predictive Modeling of Pharmaceutical Unit Operations
  • Author : Preetanshu Pandey,Rahul Bharadwaj
  • Publisher : Woodhead Publishing
  • Release : 26 September 2016
GET THIS BOOKPredictive Modeling of Pharmaceutical Unit Operations

The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality

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Bioreactors

Bioreactors
  • Author : Carl-Fredrik Mandenius
  • Publisher : John Wiley & Sons
  • Release : 16 February 2016
GET THIS BOOKBioreactors

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production,

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Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
  • Author : David A. Mitchell,Nadia Krieger,Marin Berovic
  • Publisher : Springer Science & Business Media
  • Release : 02 August 2006
GET THIS BOOKSolid-State Fermentation Bioreactors

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

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Comprehensive Biotechnology

Comprehensive Biotechnology
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 17 July 2019
GET THIS BOOKComprehensive Biotechnology

Comprehensive Biotechnology, Third Edition unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of

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Bioreactors

Bioreactors
  • Author : Goutam Saha,Alok Barua,Satyabroto Sinha
  • Publisher : CRC Press
  • Release : 01 December 2017
GET THIS BOOKBioreactors

Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to

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Biological Reaction Engineering

Biological Reaction Engineering
  • Author : Elmar Heinzle,Irving J. Dunn,John Ingham,Jiří E. Přenosil
  • Publisher : John Wiley & Sons
  • Release : 26 April 2021
GET THIS BOOKBiological Reaction Engineering

This practical book presents the modeling of dynamic biological engineering processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh

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Methods in Computational Biology

Methods in Computational Biology
  • Author : Ross Carlson,Herbert Sauro
  • Publisher : MDPI
  • Release : 03 July 2019
GET THIS BOOKMethods in Computational Biology

Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled “Methods in Computational Biology”, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the

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New Directions in Bioprocess Modeling and Control

New Directions in Bioprocess Modeling and Control
  • Author : Michael A. Boudreau,Gregory K. McMillan
  • Publisher : ISA
  • Release : 12 August 2022
GET THIS BOOKNew Directions in Bioprocess Modeling and Control

Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important

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The Prospect of Industry 5.0 in Biomanufacturing

The Prospect of Industry 5.0 in Biomanufacturing
  • Author : Pau Loke Show,Kit Wayne Chew,Tau Chuan Ling
  • Publisher : CRC Press
  • Release : 02 July 2021
GET THIS BOOKThe Prospect of Industry 5.0 in Biomanufacturing

This is the first book to present the idea of Industry 5.0 in biomanufacturing and bioprocess engineering, both upstream and downstream. The Prospect of Industry 5.0 in Biomanufacturing details the latest technologies and how they can be used efficiently and explains process analysis from an engineering point of view. In addition, it covers applications and challenges. FEATURES Describes the previous Industrial Revolution, current Industry 4.0, and how new technologies will transition toward Industry 5.0 Explains how Industry 5.0 can be applied in biomanufacturing Demonstrates new

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Techno-economics and Life Cycle Assessment of Bioreactors

Techno-economics and Life Cycle Assessment of Bioreactors
  • Author : Puranjan Mishra,Lakhveer Singh,Pooja Ghosh
  • Publisher : Elsevier
  • Release : 24 June 2022
GET THIS BOOKTechno-economics and Life Cycle Assessment of Bioreactors

Techno-economics and Life Cycle Assessment of Bioreactors: Post-Covid19 Waste Management Approach covers the emerging trends in bioreactor research, including techno-economics and life cycle assessment perspectives, both key considerations in making the anaerobic-digestion process technically feasible, economically viable and environmentally sustainable. The book is divided into three sections, with an introductory chapter on the impact of COVID-19 on existing practices of waste and resource management. Sections cover advances in bioreactor development for enhanced valorization of waste, the techno-economics of the different

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