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Brain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease
  • Author : Jacques Fantini
  • Publsiher : Academic Press
  • Release : 12 May 2015
  • ISBN : 0128004924
  • Pages : 398 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Summary:
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. Written to provide a "hands-on" approach for readers Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings Step-by-step guide to memorize and draw lipid structures Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique


Brain Lipids in Synaptic Function and Neurological Disease

Brain Lipids in Synaptic Function and Neurological Disease
  • Author : Jacques Fantini,Nouara Yahi
  • Publisher : Academic Press
  • Release : 12 May 2015
GET THIS BOOKBrain Lipids in Synaptic Function and Neurological Disease

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology

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Omega-3 Fatty Acids in Brain and Neurological Health

Omega-3 Fatty Acids in Brain and Neurological Health
  • Author : Ronald Ross Watson,Fabien De Meester
  • Publisher : Elsevier
  • Release : 25 June 2014
GET THIS BOOKOmega-3 Fatty Acids in Brain and Neurological Health

Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease

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Lipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release : 12 August 2011
GET THIS BOOKLipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

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The Role of Glycosylation in Health and Disease

The Role of Glycosylation in Health and Disease
  • Author : Gordan Lauc,Irena Trbojević-Akmačić
  • Publisher : Springer Nature
  • Release : 08 September 2021
GET THIS BOOKThe Role of Glycosylation in Health and Disease

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite

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Food for the Ageing Population

Food for the Ageing Population
  • Author : Monique Raats
  • Publisher : Elsevier
  • Release : 17 December 2008
GET THIS BOOKFood for the Ageing Population

The world’s ageing population is increasing and food professionals will have to address the needs of older generations more closely in the future. This unique volume reviews the characteristics of the ageing population as food consumers, the role of nutrition in healthy ageing and the design of food products and services for the elderly. Chapters in part one discuss aspects of the elderly’s relationship with food such as appetite and ageing, ageing and sensory perception, food and satisfaction

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Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKUpdate on Dementia

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma

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Membrane Proteins

Membrane Proteins
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release : 13 January 2022
GET THIS BOOKMembrane Proteins

Membrane Proteins, Volume 128 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated release includes the latest information on the membrane proteins

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Brain Lipids and Cholesterol in Neuropsychiatric Disorders

Brain Lipids and Cholesterol in Neuropsychiatric Disorders
  • Author : Erika Freemantle
  • Publisher : Anonim
  • Release : 19 August 2022
GET THIS BOOKBrain Lipids and Cholesterol in Neuropsychiatric Disorders

"Neuropsychiatric disorders and suicidal behaviour represent major contributions to mortality in Canada. Among the many factors associated with psychiatric disorders and suicide, alterations in lipids and cholesterol have been demonstrated both peripherally and centrally, supporting their roles as mediating variables in the underlying neuropathology. Cholesterol (CHL) regulation is a complex and dynamic system, and while animal studies also support a mediating role of CHL on brain function, efforts to determine a biological association in humans have achieved only modest gains.

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Molecular Organization of Membranes: Where Biology Meets Biophysics

Molecular Organization of Membranes: Where Biology Meets Biophysics
  • Author : Marek Cebecauer,David Holowka
  • Publisher : Frontiers Media SA
  • Release : 07 February 2018
GET THIS BOOKMolecular Organization of Membranes: Where Biology Meets Biophysics

Biological membranes protect cells and organelles from the surrounding environment, but serve also as organising platforms for physiological processes such as cell signalling. The hydrophobic core of membranes is composed of lipids and proteins influencing each other. Local membrane composition and properties define its molecular organisation and, in this way, regulate the function of all associated molecules. Therefore, studying interactions of components, biophysical properties and overall membrane dynamics provides essential information on its function in the context of cell activities.

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Sterol Regulation of Ion Channels

Sterol Regulation of Ion Channels
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 29 August 2017
GET THIS BOOKSterol Regulation of Ion Channels

Sterol Regulation of Ion Channels, Volume 80, the latest in the Current Topics in Membranes series provides outstanding content to the scientific community on relevant topics that relate to the broad field of membranes. Topics of note in this new release include Membrane structure and general mechanisms of sterol regulation of ion channels, the Regulation of ion channels by sterols as boundary lipids, the Differential effects of sterols on ion channels: specific vs. non-specific interactions, the Structural determinants of cholesterol-ion channels

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Glycosphingolipids Signaling

Glycosphingolipids Signaling
  • Author : Cheorl-Ho Kim
  • Publisher : Springer Nature
  • Release : 23 January 2021
GET THIS BOOKGlycosphingolipids Signaling

This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility,

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Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 24 October 2017
GET THIS BOOKRole of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the

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Direct Mechanisms in Cholesterol Modulation of Protein Function

Direct Mechanisms in Cholesterol Modulation of Protein Function
  • Author : Avia Rosenhouse-Dantsker,Anna N. Bukiya
  • Publisher : Springer
  • Release : 16 May 2019
GET THIS BOOKDirect Mechanisms in Cholesterol Modulation of Protein Function

In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven

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Cannabinoids in Health and Disease

Cannabinoids in Health and Disease
  • Author : Rosaria Meccariello,Rosanna Chianese
  • Publisher : BoD – Books on Demand
  • Release : 15 June 2016
GET THIS BOOKCannabinoids in Health and Disease

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use

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