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Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
  • Author : Sandro Matosevic
  • Publsiher : Academic Press
  • Release : 29 January 2021
  • ISBN : 9780128206270
  • Pages : 200 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKBreaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Summary:
Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included. The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic. Discusses translational aspects from leaders in the field to facilitate readers' understanding of clinical challenges Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites


Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
  • Author : Sandro Matosevic
  • Publisher : Academic Press
  • Release : 29 January 2021
GET THIS BOOKBreaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells

Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In

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Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
  • Author : Christopher Jackson,Michael Lim
  • Publisher : Academic Press
  • Release : 10 September 2021
GET THIS BOOKImmunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell

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Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives
  • Author : Jorge Morales Montor,Mariana Segovia
  • Publisher : Academic Press
  • Release : 01 October 2020
GET THIS BOOKImmunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune

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Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 04 October 2019
GET THIS BOOKImproving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to

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Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy
  • Author : Benjamin Bonavida,Anahid Jewett
  • Publisher : Academic Press
  • Release : 23 June 2021
GET THIS BOOKSuccesses and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application

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Self and Nonself

Self and Nonself
  • Author : Carlos López-Larrea
  • Publisher : Springer Science & Business Media
  • Release : 07 March 2012
GET THIS BOOKSelf and Nonself

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in

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Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
  • Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
  • Publisher : Academic Press
  • Release : 19 August 2019
GET THIS BOOKTheranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor

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Renal Cell Carcinoma

Renal Cell Carcinoma
  • Author : Eric A. Klein
  • Publisher : CRC Press
  • Release : 23 April 1993
GET THIS BOOKRenal Cell Carcinoma

This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell

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Cancer Immunotherapy at the Crossroads

Cancer Immunotherapy at the Crossroads
  • Author : James H. Finke,Ronald M. Bukowski
  • Publisher : Springer Science & Business Media
  • Release : 24 November 2003
GET THIS BOOKCancer Immunotherapy at the Crossroads

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions

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Transplantation Immunology

Transplantation Immunology
  • Author : Fritz H. Bach,Hugh Auchincloss
  • Publisher : Wiley-Liss
  • Release : 18 August 1995
GET THIS BOOKTransplantation Immunology

Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided

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Flow Cytometry and Cell Sorting

Flow Cytometry and Cell Sorting
  • Author : Andreas Radbruch
  • Publisher : Springer Science & Business Media
  • Release : 14 March 2013
GET THIS BOOKFlow Cytometry and Cell Sorting

The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS

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Natural Killer Cell Protocols

Natural Killer Cell Protocols
  • Author : Kerry S. Campbell,Marco Colonna
  • Publisher : Springer Science & Business Media
  • Release : 25 June 2022
GET THIS BOOKNatural Killer Cell Protocols

In Natural Killer Cell Protocols: Cellular and Molecular Methods, Kerry S. Campbell and Marco Colonna have assembled a comprehensive collection of readily reproducible methods designed to study natural killer (NK) cells from the broadest variety of viewpoints. These include not only classic techniques, but also new approaches to standard methods, newly evolved techniques that have become valuable for specific applications, and unique models for manipulating and studying NK cells. Among the advanced methods covered are those for in vitro transendothelial

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Immunotherapy – A Novel Facet of Modern Therapeutics

Immunotherapy – A Novel Facet of Modern Therapeutics
  • Author : Sujata P. Sawarkar,Vandana S. Nikam,Shariq Syed
  • Publisher : Springer Nature
  • Release : 16 December 2020
GET THIS BOOKImmunotherapy – A Novel Facet of Modern Therapeutics

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies

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