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Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
  • Author : Michael R. D'Andrea
  • Publsiher : Academic Press
  • Release : 10 October 2014
  • ISBN : 0128019883
  • Pages : 170 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKBursting Neurons and Fading Memories

Summary:
Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology A high-level text on AD pathology, and suggestions for progress in a stagnating field Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity


Bursting Neurons and Fading Memories

Bursting Neurons and Fading Memories
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 10 October 2014
GET THIS BOOKBursting Neurons and Fading Memories

Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the

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Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 21 February 2016
GET THIS BOOKIntracellular Consequences of Amyloid in Alzheimer's Disease

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid

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Alzheimer’s Turning Point

Alzheimer’s Turning Point
  • Author : Jack C. de la Torre
  • Publisher : Springer
  • Release : 25 June 2016
GET THIS BOOKAlzheimer’s Turning Point

This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored.

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Glia in Health and Disease

Glia in Health and Disease
  • Author : Tania Spohr
  • Publisher : BoD – Books on Demand
  • Release : 20 May 2020
GET THIS BOOKGlia in Health and Disease

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters.

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From Neuron to Cognition via Computational Neuroscience

From Neuron to Cognition via Computational Neuroscience
  • Author : Michael A. Arbib,James J. Bonaiuto
  • Publisher : MIT Press
  • Release : 11 November 2016
GET THIS BOOKFrom Neuron to Cognition via Computational Neuroscience

A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition. This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using computational tools to trace a path from neurons and circuits to behavior and cognition. Moreover, the chapters show how computational neuroscience—methods for modeling the causal interactions underlying neural systems—complements

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The Brain That Changes Itself

The Brain That Changes Itself
  • Author : Norman Doidge
  • Publisher : Penguin
  • Release : 15 March 2007
GET THIS BOOKThe Brain That Changes Itself

“Fascinating. Doidge’s book is a remarkable and hopeful portrait of the endless adaptability of the human brain.”—Oliver Sacks, MD, author of The Man Who Mistook His Wife for a Hat What is neuroplasticity? Is it possible to change your brain? Norman Doidge’s inspiring guide to the new brain science explains all of this and more An astonishing new science called neuroplasticity is overthrowing the centuries-old notion that the human brain is immutable, and proving that it is,

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Rewire Your Brain

Rewire Your Brain
  • Author : John B. Arden, PhD
  • Publisher : John Wiley & Sons
  • Release : 22 March 2010
GET THIS BOOKRewire Your Brain

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true.

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How We Remember

How We Remember
  • Author : Michael E. Hasselmo
  • Publisher : MIT Press
  • Release : 26 June 2022
GET THIS BOOKHow We Remember

Episodic memory proves essential for daily function, allowing us to remember where we parked the car, what time we walked the dog, or what a friend said earlier. In How We Remember, Michael Hasselmo draws on recent developments in neuroscience to present a new model describing the brain mechanisms for encoding and remembering such events as spatiotemporal trajectories. He reviews physiological breakthroughs on the regions implicated in episodic memory, including the discovery of grid cells, the cellular mechanisms of persistent

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Advances in Natural Computation

Advances in Natural Computation
  • Author : Licheng Jiao,Lipo Wang,Xinbo Gao,Jing Liu,Feng Wu
  • Publisher : Springer
  • Release : 28 September 2006
GET THIS BOOKAdvances in Natural Computation

This is volume I of the proceedings of the Second International Conference on Natural Computation, ICNC 2006. After a demanding review process 168 carefully revised full papers and 86 revised short papers were selected from 1915 submissions for presentation in two volumes. This first volume includes 130 papers related to artificial neural networks, natural neural systems and cognitive science, neural network applications, as well as evolutionary computation: theory and algorithms.

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Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
  • Author : Peter Whittle
  • Publisher : World Scientific Publishing Company
  • Release : 26 June 2022
GET THIS BOOKNeural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an associative memory must be able to cope with 'fading data', i.e., to form an inference from the data even as its memory of that data degrades. The resultant net

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Neural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers
  • Author : Peter Whittle
  • Publisher : World Scientific
  • Release : 29 July 2010
GET THIS BOOKNeural Nets and Chaotic Carriers

Neural Nets and Chaotic Carriers develops rational principles for the design of associative memories, with a view to applying these principles to models with irregularly oscillatory operation so evident in biological neural systems, and necessitated by the meaninglessness of absolute signal levels. Design is based on the criterion that an associative memory must be able to cope with “fading data”, i.e., to form an inference from the data even as its memory of that data degrades. The resultant net

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Neuroscience for Clinicians

Neuroscience for Clinicians
  • Author : Eduardo E. Benarroch
  • Publisher : Oxford University Press
  • Release : 26 June 2022
GET THIS BOOKNeuroscience for Clinicians

"The aim of this book is to provide the clinician with a comprehensive and clinical relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms, at the molecular, cellular and system levels. The content of is based on the review of information obtained from recent advances in genetic, molecular and cell biology techniques, electrophysiological recordings, brain mapping, and mouse models, emphasizing the clinical and possible therapeutic implications. Many chapters of this book

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Flow Cytometry and Cell Sorting

Flow Cytometry and Cell Sorting
  • Author : Andreas Radbruch
  • Publisher : Springer Science & Business Media
  • Release : 14 March 2013
GET THIS BOOKFlow Cytometry and Cell Sorting

The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS

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How to Build a Brain

How to Build a Brain
  • Author : Chris Eliasmith
  • Publisher : Oxford University Press
  • Release : 16 April 2013
GET THIS BOOKHow to Build a Brain

How to Build a Brain provides a detailed exploration of a new cognitive architecture - the Semantic Pointer Architecture - that takes biological detail seriously, while addressing cognitive phenomena. Topics ranging from semantics and syntax, to neural coding and spike-timing-dependent plasticity are integrated to develop the world's largest functional brain model.

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Nature Inspired Problem-Solving Methods in Knowledge Engineering

Nature Inspired Problem-Solving Methods in Knowledge Engineering
  • Author : José Mira,José R. Álvarez
  • Publisher : Springer
  • Release : 23 June 2007
GET THIS BOOKNature Inspired Problem-Solving Methods in Knowledge Engineering

The second of a two-volume set, this book constitutes the refereed proceedings of the Second International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2007, held in La Manga del Mar Menor, Spain in June 2007. It contains all the contributions connected with biologically inspired methods and techniques for solving AI and knowledge engineering problems in different application domains.

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