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Cancer Leading Proteases

Cancer Leading Proteases
  • Author : Satya Prakash Gupta
  • Publsiher : Academic Press
  • Release : 03 February 2020
  • ISBN : 0128181680
  • Pages : 526 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKCancer Leading Proteases

Summary:
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples


Cancer-Leading Proteases

Cancer-Leading Proteases
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release : 03 February 2020
GET THIS BOOKCancer-Leading Proteases

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating

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Proteolytic Signaling in Health and Disease

Proteolytic Signaling in Health and Disease
  • Author : Andre Zelanis
  • Publisher : Academic Press
  • Release : 13 October 2021
GET THIS BOOKProteolytic Signaling in Health and Disease

In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound

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Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 15 November 2017
GET THIS BOOKPathophysiological Aspects of Proteases

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making

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Proteases in Physiology and Pathology

Proteases in Physiology and Pathology
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 14 September 2017
GET THIS BOOKProteases in Physiology and Pathology

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect

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Resistance to Proteasome Inhibitors in Cancer

Resistance to Proteasome Inhibitors in Cancer
  • Author : Q. Ping Dou
  • Publisher : Springer
  • Release : 16 September 2014
GET THIS BOOKResistance to Proteasome Inhibitors in Cancer

The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors

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Proteases and Cancer

Proteases and Cancer
  • Author : Santiago Cal,Alvaro J. Obaya
  • Publisher : Humana
  • Release : 04 June 2019
GET THIS BOOKProteases and Cancer

This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography, angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily

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The Cancer Degradome

The Cancer Degradome
  • Author : Dylan Edwards,Gunilla Hoyer-Hansen,Francesco Blasi,B.F. Sloane
  • Publisher : Springer Science & Business Media
  • Release : 16 September 2008
GET THIS BOOKThe Cancer Degradome

This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

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Anticancer Drug Development

Anticancer Drug Development
  • Author : Bruce C. Baguley,David J. Kerr
  • Publisher : Elsevier
  • Release : 17 November 2001
GET THIS BOOKAnticancer Drug Development

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects

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Oxford Textbook of Oncology

Oxford Textbook of Oncology
  • Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
  • Publisher : Oxford University Press
  • Release : 28 January 2016
GET THIS BOOKOxford Textbook of Oncology

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of

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Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine
  • Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
  • Publisher : John Wiley & Sons
  • Release : 10 March 2017
GET THIS BOOKHolland-Frei Cancer Medicine

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage

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Bone Cancer

Bone Cancer
  • Author : Dominique Heymann
  • Publisher : Academic Press
  • Release : 20 August 2009
GET THIS BOOKBone Cancer

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly

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Extracellular Targeting of Cell Signaling in Cancer

Extracellular Targeting of Cell Signaling in Cancer
  • Author : James W. Janetka,Roseann M. Benson
  • Publisher : John Wiley & Sons
  • Release : 23 July 2018
GET THIS BOOKExtracellular Targeting of Cell Signaling in Cancer

International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal

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Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 19 August 2022
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

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