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Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran
  • Publsiher : Elsevier
  • Release : 14 January 2015
  • ISBN : 0444632638
  • Pages : 398 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKCarbonic Anhydrases as Biocatalysts

Summary:
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications


Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran,Giuseppina De Simone
  • Publisher : Elsevier
  • Release : 14 January 2015
GET THIS BOOKCarbonic Anhydrases as Biocatalysts

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their

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The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
  • Publisher : Birkhäuser
  • Release : 11 November 2013
GET THIS BOOKThe Carbonic Anhydrases

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene

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Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Claudiu T. Supuran,Alessio Nocentini
  • Publisher : Academic Press
  • Release : 17 July 2019
GET THIS BOOKCarbonic Anhydrases

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors

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The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKThe Carbonic Anhydrases

As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family of enzymes that solve these problems in the human body: they are responsible for converting C0 (a gas) to 2 HC0-, which is the biggest intracellular buffer, with a concomitant

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The Carbonic Anhydrases: Current and Emerging Therapeutic Targets

The Carbonic Anhydrases: Current and Emerging Therapeutic Targets
  • Author : W. Richard Chegwidden,Nicholas D. Carter
  • Publisher : Springer Nature
  • Release : 01 December 2021
GET THIS BOOKThe Carbonic Anhydrases: Current and Emerging Therapeutic Targets

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians

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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
  • Author : Susan C. Frost,Robert McKenna
  • Publisher : Springer Science & Business Media
  • Release : 22 October 2013
GET THIS BOOKCarbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic

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Carbonic Anhydrase

Carbonic Anhydrase
  • Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
  • Publisher : CRC Press
  • Release : 27 May 2004
GET THIS BOOKCarbonic Anhydrase

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in

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Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
  • Author : Claudiu T. Supuran
  • Publisher : MDPI
  • Release : 08 April 2019
GET THIS BOOKCarbonic Anhydrases and Metabolism

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient

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Diseases of the Kidney and Urinary Tract

Diseases of the Kidney and Urinary Tract
  • Author : Robert W. Schrier
  • Publisher : Lippincott Williams & Wilkins
  • Release : 26 June 2022
GET THIS BOOKDiseases of the Kidney and Urinary Tract

The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to evaluate and manage the disease process. Each of the fourteen sections is written by internationally renowned contributors and provides coverage comparable to a complete book. The first two sections review

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Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target
  • Author : Daumantas Matulis
  • Publisher : Springer
  • Release : 21 May 2019
GET THIS BOOKCarbonic Anhydrase as Drug Target

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular

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Isozymes V4

Isozymes V4
  • Author : Clement Markert
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKIsozymes V4

Isozymes, IV: Genetics and Evolution contains manuscripts presented at the Third International Conference on isozymes convened in April 1974 at Yale University. Separating 58 manuscripts into chapters, this book begins by elucidating the usefulness of isozymes as effective markers in studies of various aspects of genetics and evolution. Specific discussions are given to isozymes in evolutionary systematics and isozyme polymorphism maintenance mechanisms viewed from the standpoint of population genetics. This book explains multiple allelism and isozyme diversity in human populations. It also

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Drug Design of Zinc-Enzyme Inhibitors

Drug Design of Zinc-Enzyme Inhibitors
  • Author : Claudiu T. Supuran,Jean-Yves Winum
  • Publisher : John Wiley & Sons
  • Release : 22 October 2009
GET THIS BOOKDrug Design of Zinc-Enzyme Inhibitors

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug

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Carbonic Anhydrase as Drug Target

Carbonic Anhydrase as Drug Target
  • Author : Daumantas Matulis
  • Publisher : Springer
  • Release : 03 June 2019
GET THIS BOOKCarbonic Anhydrase as Drug Target

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular

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