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Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy
  • Publsiher : Academic Press
  • Release : 14 May 2021
  • ISBN : 0128176458
  • Pages : 350 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKChemical Biology of the Genome

Summary:
Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery


Chemical Biology of the Genome

Chemical Biology of the Genome
  • Author : Siddhartha Roy,Tapas K. Kundu
  • Publisher : Academic Press
  • Release : 14 May 2021
GET THIS BOOKChemical Biology of the Genome

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout,

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The Chemical Biology of Phosphorus

The Chemical Biology of Phosphorus
  • Author : Christopher T. Walsh
  • Publisher : Royal Society of Chemistry
  • Release : 30 October 2020
GET THIS BOOKThe Chemical Biology of Phosphorus

Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: "where there is life, there is phosphorus". Phosphorus chemical biology underlies most of life's reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of ATP every day, required to run almost all metabolic and mechanical events in cells. Authored by a renowned biochemist, The Chemical Biology of Phosphorus provides an in-depth, unifying chemical approach to the logic and

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The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
  • Author : Stefan Jurga,Jan Barciszewski
  • Publisher : Springer Nature
  • Release : 01 October 2020
GET THIS BOOKThe Chemical Biology of Long Noncoding RNAs

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A

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Chemical Genomics

Chemical Genomics
  • Author : Haian Fu
  • Publisher : Cambridge University Press
  • Release : 13 February 2012
GET THIS BOOKChemical Genomics

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals;

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Fundamentals of Molecular Structural Biology

Fundamentals of Molecular Structural Biology
  • Author : Subrata Pal
  • Publisher : Academic Press
  • Release : 13 August 2019
GET THIS BOOKFundamentals of Molecular Structural Biology

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing

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Chemical Biology of Glycoproteins

Chemical Biology of Glycoproteins
  • Author : Zhongping Tan,Lai-Xi Wang
  • Publisher : Royal Society of Chemistry
  • Release : 20 March 2017
GET THIS BOOKChemical Biology of Glycoproteins

Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools

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The Music of Life

The Music of Life
  • Author : Denis Noble
  • Publisher : Oxford University Press
  • Release : 14 February 2008
GET THIS BOOKThe Music of Life

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes.But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative

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The Chemical Biology of Human Vitamins

The Chemical Biology of Human Vitamins
  • Author : Christopher T. Walsh,Yi Tang
  • Publisher : Royal Society of Chemistry
  • Release : 14 September 2018
GET THIS BOOKThe Chemical Biology of Human Vitamins

As humans evolved from primordial organisms they lost the capacity to make certain essential molecules. By their very absence in specific pathologies and diseases, the thirteen human vitamins were discovered and their crucial role in metabolism revealed. This textbook provides a thorough chemocentric view on the key small molecules of life, the human vitamins and their active coenzyme forms. Detailing how their unique chemistries control the interconversion and the flux of hundreds of central human metabolites, The Chemical Biology of

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Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release : 19 September 2017
GET THIS BOOKAdvancing Development of Synthetic Gene Regulators

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates

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A Primer of Molecular Population Genetics

A Primer of Molecular Population Genetics
  • Author : Asher D. Cutter
  • Publisher : Oxford University Press, USA
  • Release : 12 August 2022
GET THIS BOOKA Primer of Molecular Population Genetics

What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the

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Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 28 March 2021
GET THIS BOOKReprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens,

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Aging of the Genome

Aging of the Genome
  • Author : Jan Vijg
  • Publisher : Oxford University Press
  • Release : 25 January 2007
GET THIS BOOKAging of the Genome

Aging has long been ascribed to the gradual accumulation of mutations in the genome. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms resulting from recent advances in functional genomics and systems biology.

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