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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publsiher : Academic Press
  • Release : 20 September 2016
  • ISBN : 0128028114
  • Pages : 316 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKDrug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Summary:
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource


Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release : 20 September 2016
GET THIS BOOKDrug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies,

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Drug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease
  • Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
  • Publisher : Elsevier
  • Release : 27 June 2015
GET THIS BOOKDrug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery.

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Neurobiology of Huntington’s Disease

Neurobiology of Huntington’s Disease
  • Author : Donald C. Lo,Robert E. Hughes
  • Publisher : CRC Press
  • Release : 02 July 2010
GET THIS BOOKNeurobiology of Huntington’s Disease

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding

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Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release : 05 April 2017
GET THIS BOOKDesign of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of

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Nanomedical Drug Delivery for Neurodegenerative Diseases

Nanomedical Drug Delivery for Neurodegenerative Diseases
  • Author : Awesh K. Yadav,Rahul Shukla,S.J.S. Flora
  • Publisher : Academic Press
  • Release : 10 March 2022
GET THIS BOOKNanomedical Drug Delivery for Neurodegenerative Diseases

Nanomedical Drug Delivery for Neurodegenerative Diseases opens the door for promising approaches and advances in the diagnosis and treatment of various neurodegenerative diseases. The contents of the book comprise all the aspects related to the design, synthesis, and application of different nanodrug delivery systems in the treatment of neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and motor neuron diseases. This book explores how nanoparticulate drug carriers can improve therapeutic efficacy by selecting a suitable design strategy. Nanomedical

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Anti-aging Drugs

Anti-aging Drugs
  • Author : Alexander M Vaiserman
  • Publisher : Royal Society of Chemistry
  • Release : 01 February 2017
GET THIS BOOKAnti-aging Drugs

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points

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Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders
  • Author : Preetham Elumalai,Sreeja Lakshmi
  • Publisher : Springer Nature
  • Release : 22 May 2022
GET THIS BOOKFunctional Foods and Therapeutic Strategies for Neurodegenerative Disorders

This book provides a comprehensive summary of the latest knowledge regarding functional foods and new therapeutic strategies for neurodegenerative disorders through explaining specific mechanisms for natural remedies and functional foods as well as alternative treatment and supplementary approaches for neurodegenerative diseases. Many relevant topics are covered, including role of prebiotics, recent applications for dietary polyphenols, marine bioactive compounds for neuro disorders, and age-related disorders. The roles of various remedies and functional foods are explained for various types of diseases, and

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Drug Repurposing

Drug Repurposing
  • Author : Farid A. Badria
  • Publisher : BoD – Books on Demand
  • Release : 02 December 2020
GET THIS BOOKDrug Repurposing

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to

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Principles of Neurochemistry

Principles of Neurochemistry
  • Author : Bijo Mathew,Della Grace Thomas Parambi
  • Publisher : Springer Nature
  • Release : 21 September 2020
GET THIS BOOKPrinciples of Neurochemistry

This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research.

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The Right Therapy for Neurological Disorders

The Right Therapy for Neurological Disorders
  • Author : E. Beghi,G. Logroscino
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 26 July 2016
GET THIS BOOKThe Right Therapy for Neurological Disorders

Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists,

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Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease
  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release : 30 December 2016
GET THIS BOOKNeuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is

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Drug Repositioning

Drug Repositioning
  • Author : Joel Dudley,Laura Berliocchi
  • Publisher : CRC Press
  • Release : 14 July 2017
GET THIS BOOKDrug Repositioning

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches

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Frontiers in Clinical Drug Research - CNS and Neurological Disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders
  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release : 21 December 2017
GET THIS BOOKFrontiers in Clinical Drug Research - CNS and Neurological Disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on

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