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Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators
  • Author : Marcela Bolontrade
  • Publsiher : Academic Press
  • Release : 24 October 2016
  • ISBN : 0128031034
  • Pages : 642 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKMesenchymal Stromal Cells as Tumor Stromal Modulators

Summary:
Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges


Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators
  • Author : Marcela Bolontrade,Mariana García
  • Publisher : Academic Press
  • Release : 24 October 2016
GET THIS BOOKMesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which

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Mesenchymal Stromal Cells

Mesenchymal Stromal Cells
  • Author : Peiman Hematti,Armand Keating
  • Publisher : Springer Science & Business Media
  • Release : 16 January 2013
GET THIS BOOKMesenchymal Stromal Cells

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are

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Stromal Cells

Stromal Cells
  • Author : Mani T. Valarmathi
  • Publisher : BoD – Books on Demand
  • Release : 23 January 2019
GET THIS BOOKStromal Cells

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and

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The Biology and Therapeutic Application of Mesenchymal Cells - Set

The Biology and Therapeutic Application of Mesenchymal Cells - Set
  • Author : Kerry Atkinson
  • Publisher : John Wiley & Sons
  • Release : 17 January 2017
GET THIS BOOKThe Biology and Therapeutic Application of Mesenchymal Cells - Set

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited,

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Mesenchymal Stromal Cells

Mesenchymal Stromal Cells
  • Author : Peiman Hematti,Armand Keating
  • Publisher : Springer Science & Business Media
  • Release : 16 January 2013
GET THIS BOOKMesenchymal Stromal Cells

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are

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Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2012
GET THIS BOOKMesenchymal Stem Cell Therapy

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host

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Mesenchymal Stem Cells

Mesenchymal Stem Cells
  • Author : Phuc Van Pham
  • Publisher : BoD – Books on Demand
  • Release : 29 November 2017
GET THIS BOOKMesenchymal Stem Cells

Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed.

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Mesenchymal Stromal Cells (MSCs)

Mesenchymal Stromal Cells (MSCs)
  • Author : Randy Morrison
  • Publisher : Anonim
  • Release : 17 October 2021
GET THIS BOOKMesenchymal Stromal Cells (MSCs)

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action

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The Role of Mesenchymal Stromal Cells and Classical Dendritic Cells in the Maintenance and Regulation of the Bone Marrow Niche

The bone marrow niche is an important microenvironment for the regulation of normal and malignant hematopoiesis. The first discovered niche component is mesenchymal stromal cells, which are the major source for the production and secretion of multiple niche factors. Mesenchymal stromal cells are heterogeneous and various transgenes have been used to target non-identical but overlapping subpopulations. To further characterize the heterogeneity of mesenchymal stromal cells, we tested the targeting specificity of three tissue-specific Cre-recombinase transgenes. We show that in addition

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Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
  • Author : Ahmed H.K. El-Hashash
  • Publisher : Academic Press
  • Release : 07 January 2020
GET THIS BOOKMesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural

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Mesenchymal Stem Cells - Basics and Clinical Application I

Mesenchymal Stem Cells - Basics and Clinical Application I
  • Author : Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper
  • Publisher : Springer
  • Release : 08 July 2014
GET THIS BOOKMesenchymal Stem Cells - Basics and Clinical Application I

Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Bühring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic

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The Biology and Therapeutic Application of Mesenchymal Cells

The Biology and Therapeutic Application of Mesenchymal Cells
  • Author : Kerry Atkinson
  • Publisher : John Wiley & Sons
  • Release : 08 November 2016
GET THIS BOOKThe Biology and Therapeutic Application of Mesenchymal Cells

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited,

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Mesenchymal Stromal Cells

Mesenchymal Stromal Cells
  • Author : Hematti Peiman,Sowmya Viswanathan
  • Publisher : Academic Press
  • Release : 11 August 2016
GET THIS BOOKMesenchymal Stromal Cells

Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues,

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Stem Cell Biology in Normal Life and Diseases

Stem Cell Biology in Normal Life and Diseases
  • Author : Kamran Alimoghaddam
  • Publisher : BoD – Books on Demand
  • Release : 08 May 2013
GET THIS BOOKStem Cell Biology in Normal Life and Diseases

Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical

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