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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala
  • Publsiher : Academic Press
  • Release : 30 April 2016
  • ISBN : 0128005335
  • Pages : 394 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKNeuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Summary:
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture


Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala,Chiara Verpelli
  • Publisher : Academic Press
  • Release : 30 April 2016
GET THIS BOOKNeuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders.

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A Time for Metabolism and Hormones

A Time for Metabolism and Hormones
  • Author : Paolo Sassone-Corsi,Yves Christen
  • Publisher : Springer
  • Release : 04 April 2016
GET THIS BOOKA Time for Metabolism and Hormones

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the

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Autism

Autism
  • Author : Michael Fitzgerald,Jane Yip
  • Publisher : BoD – Books on Demand
  • Release : 12 April 2017
GET THIS BOOKAutism

This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness,

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Neuronal Stress Pathways Influence Synaptic Development and Nervous System Function in Drosophila Melanogaster

Synaptic development is a complex and highly orchestrated process in which the nervous system must build appropriately sized and sufficiently strong connections between neurons and their targets. Many neurodevelopmental disorders are caused by dysregulation of the mechanisms that promote the formation of normal synaptic connections. Here, I show that dysregulation of neuronal stress pathways during development negatively impacts synaptic growth and functionality. First, I explore the Drosophila model of Fragile X Syndrome, a common and debilitating disorder that causes intellectual

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Cassidy and Allanson's Management of Genetic Syndromes

Cassidy and Allanson's Management of Genetic Syndromes
  • Author : John C. Carey,Suzanne B. Cassidy,Agatino Battaglia,David Viskochil
  • Publisher : John Wiley & Sons
  • Release : 27 January 2021
GET THIS BOOKCassidy and Allanson's Management of Genetic Syndromes

The most recent update to one of the most essential references on medical genetics Cassidy and Allanson's Management of Genetic Syndromes, 4th Edition is the latest version of a classic text in medical genetics. With newly covered disorders and cutting-edge, up-to-date information, this resource remains the most crucial reference on the management of genetic syndromes for students, clinicians, and researchers in the field of medical genetics. The 4th edition includes current information on the identification of genetic syndromes (including newly

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The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
  • Author : Joseph D. Buxbaum,Patrick R. Hof
  • Publisher : Academic Press
  • Release : 27 October 2021
GET THIS BOOKThe Neuroscience of Autism Spectrum Disorders

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the

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Neural and Synaptic Defects in Autism Spectrum Disorders

Neural and Synaptic Defects in Autism Spectrum Disorders
  • Author : Hansen Wang,Laurie C. Doering
  • Publisher : Frontiers Media SA
  • Release : 07 July 2015
GET THIS BOOKNeural and Synaptic Defects in Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of

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Autism Spectrum Disorder

Autism Spectrum Disorder
  • Author : Michael Fitzgerald
  • Publisher : BoD – Books on Demand
  • Release : 02 April 2015
GET THIS BOOKAutism Spectrum Disorder

This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism

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The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)

The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)
  • Author : Flora Tassone,Elizabeth M. Berry-Kravis
  • Publisher : Springer Science & Business Media
  • Release : 02 June 2010
GET THIS BOOKThe Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)

In Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), the editors present information on all aspects of FXTAS, including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed. The book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS and their families, as well as presenting the molecular basis for disease that may lead to the

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Latest Findings in Intellectual and Developmental Disabilities Research

Latest Findings in Intellectual and Developmental Disabilities Research
  • Author : Uner Tan
  • Publisher : BoD – Books on Demand
  • Release : 15 February 2012
GET THIS BOOKLatest Findings in Intellectual and Developmental Disabilities Research

Intellectual and Developmental Disabilities presents reports on a wide range of areas in the field of neurological and intellectual disability, including habitual human quadrupedal locomotion with associated cognitive disabilities, Fragile X syndrome, autism spectrum disorders, Down syndrome, and intellectual developmental disability among children in an African setting. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics behind the conditions to new and innovative therapeutic approaches.

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Changes in Prevalence of Parent-reported Autism Spectrum Disorder in School-aged U.S. Children: 2007 to 2011-2012

Changes in Prevalence of Parent-reported Autism Spectrum Disorder in School-aged U.S. Children: 2007 to 2011-2012
  • Author : Stephen J. Blumberg,Matthew D. Bramlett,Michael D. Kogan,Laura A. Schieve,Jessica R. Jones,Michael C. Lu
  • Publisher : Anonim
  • Release : 27 October 2021
GET THIS BOOKChanges in Prevalence of Parent-reported Autism Spectrum Disorder in School-aged U.S. Children: 2007 to 2011-2012

Biometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders
  • Author : Andreas Grabrucker
  • Publisher : Academic Press
  • Release : 08 July 2020
GET THIS BOOKBiometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and

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Autism Spectrum Disorders: From Genotypes to Phenotypes

Autism Spectrum Disorders: From Genotypes to Phenotypes
  • Author : Valsamma Eapen,Andrew J. Whitehouse,Charles Claudianos,Rudi Crncec
  • Publisher : Frontiers Media SA
  • Release : 10 December 2015
GET THIS BOOKAutism Spectrum Disorders: From Genotypes to Phenotypes

This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during

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