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PAKs RAC CDC42 p21 activated Kinases

PAKs  RAC CDC42  p21  activated Kinases
  • Author : Hiroshi Maruta
  • Publsiher : Newnes
  • Release : 23 January 2013
  • ISBN : 0124072100
  • Pages : 276 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPAKs RAC CDC42 p21 activated Kinases

Summary:
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.


PAKs, RAC/CDC42 (p21)-activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases
  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Release : 23 January 2013
GET THIS BOOKPAKs, RAC/CDC42 (p21)-activated Kinases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen

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Cytoskeleton and Small G Proteins

Cytoskeleton and Small G Proteins
  • Author : Philippe Jeanteur
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKCytoskeleton and Small G Proteins

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

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Estrogens and Memory

Estrogens and Memory
  • Author : Karyn M. Frick
  • Publisher : Oxford University Press, USA
  • Release : 19 August 2022
GET THIS BOOKEstrogens and Memory

"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the

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Interaction Between a Novel P21 Activated Kinase (PAK6) and Androgen Receptor in Prostate Cancer

The androgen-signaling pathway is important for the growth and progression of prostate cancer. The cell cycle signaling regulated by the mitogen activated protein/extracellular-signal-regulated kinase (MAPK/ERK) have been linked to tumorigenesis and tumor progression. The p2l-activated kinases (PAKs) are members of a growing class of Rac/Cdc42-associated Ste20-like ser/thr protein kinases. Recent studies have shown that MAPK/ERK signaling can be mediated via Cdc42/Rac-stimulation of PAK activity. Recently, we demonstrated a specific interaction between

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Tight Junctions

Tight Junctions
  • Author : Lorenza Gonz├ílez-Mariscal
  • Publisher : Springer Nature
  • Release : 31 May 2022
GET THIS BOOKTight Junctions

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution

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AACR 2022 Proceedings: Part A Online-Only and April 10

AACR 2022 Proceedings: Part A Online-Only and April 10
  • Author : American Association for Cancer Research
  • Publisher : CTI Meeting Technology
  • Release : 09 May 2022
GET THIS BOOKAACR 2022 Proceedings: Part A Online-Only and April 10

The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

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Cell Signalling in Prokaryotes and Lower Metazoa

Cell Signalling in Prokaryotes and Lower Metazoa
  • Author : I. Fairweather
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKCell Signalling in Prokaryotes and Lower Metazoa

Cell signalling lies at the heart of many biological processes and currently is the focus of intense research interest. In multicellular organisms, it is central to how different types of cell communicate with each other and how they detect and respond to extracellular signals. Intercellular communication is vital to single-celled organisms as well, allowing them to respond to environmental cues and signals. To date, much of the understanding of signalling mechanisms has come from research on specific cell types (eg

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Characterization of the P21-activated Kinase Pak During Drosophila Oogenesis

Characterization of the P21-activated Kinase Pak During Drosophila Oogenesis
  • Author : Stephanie Vlachos
  • Publisher : Anonim
  • Release : 19 August 2022
GET THIS BOOKCharacterization of the P21-activated Kinase Pak During Drosophila Oogenesis

Understanding the mechanisms involved in tissue reorganization and organ formation are fundamental questions that are of particular interest to those studying epithelial morphogenesis. Model organisms such as Drosophila melanogaster have been instrumental in identifying key components required for cellular processes that are critical for tissue morphogenesis as a whole. These include cell fate specification, cell shape change, cell growth and cell migration. The Rho subfamily of small GTPases Rho, Rac and Cdc42, are master regulators of actin cytoskeletal dynamics and

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Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release : 28 March 2017
GET THIS BOOKLeucine-Rich Repeat Kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It

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Regulation of Gene Expression in the Tumor Environment

Regulation of Gene Expression in the Tumor Environment
  • Author : Menashe Bar-Eli
  • Publisher : Springer Science & Business Media
  • Release : 25 August 2008
GET THIS BOOKRegulation of Gene Expression in the Tumor Environment

It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and

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