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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection
  • Author : Naseer Ahmed
  • Publsiher : Academic Press
  • Release : 30 May 2019
  • ISBN : 0128182539
  • Pages : 140 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Summary:
Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies


Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection
  • Author : Naseer Ahmed
  • Publisher : Academic Press
  • Release : 30 May 2019
GET THIS BOOKPathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and



Cerebral Ischemic Reperfusion Injuries (CIRI)

Cerebral Ischemic Reperfusion Injuries (CIRI)
  • Author : Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
  • Publisher : Springer
  • Release : 29 June 2018
GET THIS BOOKCerebral Ischemic Reperfusion Injuries (CIRI)

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular


The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases
  • Author : Kenneth V. Honn,Darryl C. Zeldin
  • Publisher : Springer Nature
  • Release : 27 September 2019
GET THIS BOOKThe Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived


Metabolism of Human Diseases

Metabolism of Human Diseases
  • Author : Eckhard Lammert,Martin Zeeb
  • Publisher : Springer Science & Business Media
  • Release : 02 June 2014
GET THIS BOOKMetabolism of Human Diseases

“Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell


Sudden arrhythmic death: from basic science to clinical practice

Sudden arrhythmic death: from basic science to clinical practice
  • Author : Gareth D. Matthews
  • Publisher : Frontiers E-books
  • Release : 02 October 2014
GET THIS BOOKSudden arrhythmic death: from basic science to clinical practice

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in


The Adenosine Receptors

The Adenosine Receptors
  • Author : Pier Andrea Borea,Katia Varani,Stefania Gessi,Stefania Merighi,Fabrizio Vincenzi
  • Publisher : Humana Press
  • Release : 28 July 2018
GET THIS BOOKThe Adenosine Receptors

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and


Vascular Development

Vascular Development
  • Author : Derek J. Chadwick,Jamie A. Goode
  • Publisher : John Wiley & Sons
  • Release : 20 August 2007
GET THIS BOOKVascular Development

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that


Phytopharmaceuticals for Brain Health

Phytopharmaceuticals for Brain Health
  • Author : Shahnaz Subhan,Manashi Bagchi
  • Publisher : CRC Press
  • Release : 27 September 2017
GET THIS BOOKPhytopharmaceuticals for Brain Health

Research studies demonstrate diet and proper nutrition in conjunction with cognitive, mental, social, and physical activities can significantly help in improving brain health with advancing age, and potentially reduce the risk of cognitive decline. These studies of phytopharmaceuticals and medicinal plants, demonstrate the efficacy of Huperzine A, berry anthocyanins, trans-resveratrol, Ginkgo biloba, Bacopa monniera, Centella asiatica, tocotrienols, and palm oil in boosting brain health and physical well-being. In addition, consumption of marine fishes and general seafood is recommended for long-term


Advances in Experimental Surgery

Advances in Experimental Surgery
  • Author : Paulo N. Martins
  • Publisher : Anonim
  • Release : 01 November 2017
GET THIS BOOKAdvances in Experimental Surgery

Experimental surgery is an important link for the development in clinical surgery, research and teaching. Experimental surgery was part of the most important surgical discoveries in the past century. Since 1901 nine Nobel Prizes have been awarded to the pioneers had remarkable achievements in the basic or practical surgery. In recent 20 years, experimental surgery has achieved new advances, like laparoscopic and robotic surgery, tissue engineering, and gene therapy which are widely applied in clinic surgery. The present book covers wide experimental


Nanozymology

Nanozymology
  • Author : Xiyun Yan
  • Publisher : Springer Nature
  • Release : 30 January 2020
GET THIS BOOKNanozymology

This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for


The Chemokine Receptors

The Chemokine Receptors
  • Author : Jeffrey K. Harrison,Nicholas W. Lukacs
  • Publisher : Springer Science & Business Media
  • Release : 17 November 2007
GET THIS BOOKThe Chemokine Receptors

This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.



Endogenous Neuroprotection

Endogenous Neuroprotection
  • Author : Bernhard Schaller
  • Publisher : Nova Publishers
  • Release : 25 February 2021
GET THIS BOOKEndogenous Neuroprotection

Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.


Regulation of Cardiac Contractility

Regulation of Cardiac Contractility
  • Author : R. John Solaro
  • Publisher : Biota Publishing
  • Release : 01 April 2011
GET THIS BOOKRegulation of Cardiac Contractility

Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension