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Pharmacoepigenetics

Pharmacoepigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 04 June 2019
GET THIS BOOKPharmacoepigenetics

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the

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Novel Perspectives in Cancer Chemoprevention Via Nrf2 Pathway

Novel Perspectives in Cancer Chemoprevention Via Nrf2 Pathway
  • Author : Tien-Yuan Wu
  • Publisher : Anonim
  • Release : 28 January 2022
GET THIS BOOKNovel Perspectives in Cancer Chemoprevention Via Nrf2 Pathway

The cancer chemoprevention is the strategy of blocking or slowing the onset of premalignant tumors and decreases the incidence of cancer with relatively nontoxic chemical substance. More importantly, Nrf2 and Nrf2-antioxidant response element (ARE) pathway plays a critical role in the cancer chemoprevention. Studies of the induction of Nrf2 and subsequent phase II detoxifying/antioxidant drug metabolism enzymes expression by phytochemicals in vivo or in vitro are considered as a major topic. This thesis will focus on the factors

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Toxicoepigenetics

Toxicoepigenetics
  • Author : Shaun D. McCullough,Dana Dolinoy
  • Publisher : Academic Press
  • Release : 02 November 2018
GET THIS BOOKToxicoepigenetics

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects

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Medical Epigenetics

Medical Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 27 August 2021
GET THIS BOOKMedical Epigenetics

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate

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Pharmacogenomics

Pharmacogenomics
  • Author : Yui-Wing Francis Lam,Larisa H. Cavallari
  • Publisher : Academic Press
  • Release : 12 February 2013
GET THIS BOOKPharmacogenomics

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field

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Prognostic Epigenetics

Prognostic Epigenetics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 01 November 2019
GET THIS BOOKPrognostic Epigenetics

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can

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Topics on Drug Metabolism

Topics on Drug Metabolism
  • Author : James Paxton
  • Publisher : BoD – Books on Demand
  • Release : 22 February 2012
GET THIS BOOKTopics on Drug Metabolism

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and

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Pharmacogenomics

Pharmacogenomics
  • Author : Yui-Wing Francis Lam,Stuart R. Scott
  • Publisher : Academic Press
  • Release : 27 November 2018
GET THIS BOOKPharmacogenomics

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies,

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Personalized Epigenetics

Personalized Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release : 28 April 2015
GET THIS BOOKPersonalized Epigenetics

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology

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Clinical DNA Variant Interpretation

Clinical DNA Variant Interpretation
  • Author : Conxi Lázaro,Jordan Lerner-Ellis,Amanda Spurdle
  • Publisher : Academic Press
  • Release : 27 February 2021
GET THIS BOOKClinical DNA Variant Interpretation

Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency,

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Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic
  • Author : Jeffrey Laurence
  • Publisher : Academic Press
  • Release : 30 December 2016
GET THIS BOOKTranslating Epigenetics to the Clinic

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders

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Handbook of Epigenetics

Handbook of Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release : 21 November 2010
GET THIS BOOKHandbook of Epigenetics

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and

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Epigenetics and Reproductive Health

Epigenetics and Reproductive Health
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 12 September 2020
GET THIS BOOKEpigenetics and Reproductive Health

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted

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Pharmacogenomics

Pharmacogenomics
  • Author : Werner Kalow,Urs B. Meyer,Rachel F. Tyndale
  • Publisher : CRC Press
  • Release : 08 May 2001
GET THIS BOOKPharmacogenomics

"Summarizes the history of, and available applications, techniques, and approaches to, pharmacogenomics--improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design, and increasing the chances of successful clinical trials and patient outcomes. Compares pharmacogenomics to pharmacogenetics, focusing on the essential components that incorporate individual genetic variations to drug regimens resulting in different responses to therapeutics."

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10 Years of Pharmacogenetics and Pharmacogenomics

10 Years of Pharmacogenetics and Pharmacogenomics
  • Author : Jose Agundez
  • Publisher : Frontiers Media SA
  • Release : 08 July 2020
GET THIS BOOK10 Years of Pharmacogenetics and Pharmacogenomics

The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board

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