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Phenotypic Switching

Phenotypic Switching
  • Author : Herbert Levine
  • Publsiher : Academic Press
  • Release : 10 June 2020
  • ISBN : 012817997X
  • Pages : 762 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPhenotypic Switching

Summary:
Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field


Phenotypic Switching

Phenotypic Switching
  • Author : Herbert Levine,Mohit Kumar Jolly,Prakash Kulkarni,Vidyanand Nanjundiah
  • Publisher : Academic Press
  • Release : 10 June 2020
GET THIS BOOKPhenotypic Switching

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance,


A Mechanistic and Functional Study of White-opaque Phenotypic Switching in Candida Albicans

A Mechanistic and Functional Study of White-opaque Phenotypic Switching in Candida Albicans
  • Author : Mathew Gregory Miller
  • Publisher : Anonim
  • Release : 09 March 2021
GET THIS BOOKA Mechanistic and Functional Study of White-opaque Phenotypic Switching in Candida Albicans

Candida albicans is a major fungal pathogen of humans. It is a harmless commensal in healthy individuals, but it can cause serious infections in immune-compromised hosts. C. albicans undergoes a meta-stable and reversible switch between two distinct cell types known as white and opaque. The role of white-opaque switching in the biology of C. albicans was originally not well understood. We discovered an unexpected relationship between white-opaque switching and the sexual cycle of C. albicans . The mating type locus of


Candida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host

Candida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host
  • Author : Brittany Gianetti
  • Publisher : Anonim
  • Release : 09 March 2021
GET THIS BOOKCandida Albicans Phenotypic Switching and Functional Plasticity in the Mammalian Host

In order to determine the host signals and fungal signaling pathways that control the white-GUT switch and drive commensalism, we developed an in vitro system to induce switching behavior and screened a library of C. albicans signaling mutants. We identified three fungal signaling pathways (Hog1, Rim101, and PKA), previously associated with other morphological transitions, which promote GUT cell formation. Together these studies help to understand how C. albicans' phenotypic plasticity influences its interactions with the mammalian host.


Inflammatory Disorders - Part B

Inflammatory Disorders - Part B
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release : 01 March 2020
GET THIS BOOKInflammatory Disorders - Part B

Inflammatory Disorders - Part B, Volume 120 explores inflammation in the immune system and how the body's own cells or tissues may cause abnormal inflammation, thus resulting in chronic pain, redness, swelling, stiffness, and damage to normal tissues. Chapters in this updated volume include Proteins in monogenic autoinflammatory disorders, Virulence factors and their roles in periodontal disease pathogenesis, Role of Heat shock proteins in Inflammatory disorder Rheumatoid Arthritis, Novel targeted therapies for Crohn's disease: Recent progress and future perspectives, Dietary plant


Marsh and Martin's Oral Microbiology - E-Book

Marsh and Martin's Oral Microbiology - E-Book
  • Author : Philip D. Marsh,Michael A. O. Lewis,Helen Rogers,Dr David Williams, BSC (Hons) PhD,Melanie Wilson
  • Publisher : Churchill Livingstone
  • Release : 13 May 2016
GET THIS BOOKMarsh and Martin's Oral Microbiology - E-Book

Now expanded with the latest information of relevance to current dental practice, Oral Microbiology retains its unique ecological approach to the subject which helps the reader determine whether an organism will have a pathogenic or commensal relationship at a given site. In the new edition, greater emphasis is placed on the role of current molecular biology techniques in the understanding of oral microbes. The book also provides insight into current therapeutic and prophylactic antibiotic use, infection control, and the relationships


Interactions Between Phenotypic Switching, Gene Network Dynamics and Evolutionary Dynamics in Growing Cell Populations

Gene expression is a stochastic biological processes that controls the different phenotypes of an organism depending on the environment. High-resolution single cell measurements show that genetically identical cells can be different from each other even in a homogeneous environment, leading a spectrum of phenotypes with different cellular fitnesses that can reversibly switch between phenotypes. How population-level properties emerge from single cell behavior and how mutants emerge and spread in such populations is unclear. In this thesis, we developed mathematical models







Clinical Mycology

Clinical Mycology
  • Author : Elias J. Anaissie
  • Publisher : Anonim
  • Release : 09 March 2021
GET THIS BOOKClinical Mycology

The first textbook of mycology ever to focus on the management of patients with fungal infections, CLINICAL MYCOLOGY represents an expert, authoritative examination of clinical problem-solving approaches to diagnosis and management. It offers specific recommendations for understanding, controlling, and preventing fungal infections based on underlying principles of epidemiology and infection control policy, pathogenesis, immunology, histopathology, and laboratory diagnosis and antifungal therapy. The book also covers etiologic agents of disease, fungal infections in special hosts such as pediatric patients and patients


Oral Manifestations of HIV Infection

Oral Manifestations of HIV Infection
  • Author : John S. Greenspan,Deborah Greenspan
  • Publisher : Quintessence Publishing (IL)
  • Release : 09 March 1995
GET THIS BOOKOral Manifestations of HIV Infection

Brings together the papers presented at this important 1993 workshop. Addressed is a wide array of issues of interest to the dental practitioner and researcher, from oral lesions to periodontal concerns to provision of care and infection control practices. [editor].