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Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publsiher : John Wiley & Sons
  • Release : 17 February 2012
  • ISBN : 1118140303
  • Pages : 450 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPhysiologically Based Pharmacokinetic PBPK Modeling and Simulations

Summary:
The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.


Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Release : 17 February 2012
GET THIS BOOKPhysiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand


Physiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling
  • Author : Jeffrey W. Fisher,Jeffery M. Gearhart,Zhoumeng Lin
  • Publisher : Academic Press
  • Release : 20 May 2020
GET THIS BOOKPhysiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety


Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
  • Publisher : John Wiley & Sons
  • Release : 14 June 2005
GET THIS BOOKPhysiologically Based Pharmacokinetic Modeling

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated


Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
  • Author : Johan Gabrielsson,Daniel Weiner
  • Publisher : CRC Press
  • Release : 30 November 2001
GET THIS BOOKPharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between


New Technologies for Toxicity Testing

New Technologies for Toxicity Testing
  • Author : Michael Balls,Robert D. Combes,Nirmala Bhogal
  • Publisher : Springer Science & Business Media
  • Release : 22 March 2012
GET THIS BOOKNew Technologies for Toxicity Testing

The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed


Fundamentals of Pediatric Drug Dosing

Fundamentals of Pediatric Drug Dosing
  • Author : Iftekhar Mahmood,Gilbert Burckart
  • Publisher : Springer
  • Release : 28 October 2016
GET THIS BOOKFundamentals of Pediatric Drug Dosing

Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children.


Metabolite Safety in Drug Development

Metabolite Safety in Drug Development
  • Author : Suzanne L. Iverson
  • Publisher : John Wiley & Sons
  • Release : 01 August 2016
GET THIS BOOKMetabolite Safety in Drug Development

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to


Toxicokinetics and Risk Assessment

Toxicokinetics and Risk Assessment
  • Author : John C. Lipscomb,Edward V. Ohanian
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKToxicokinetics and Risk Assessment

Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human healt


Ecotoxicology Modeling

Ecotoxicology Modeling
  • Author : James Devillers
  • Publisher : Springer Science & Business Media
  • Release : 07 August 2009
GET THIS BOOKEcotoxicology Modeling

Ecotoxicology Modeling is a comprehensive and well-documented text providing a collection of computational methods to the ecotoxicologists primarily interested in the study of the adverse effects of chemicals, their mechanisms of action and/or their environmental fate and behavior. Avoiding mathematical jargon, the book presents numerous case studies to enable the reader to understand the interest but also the limitations of linear and nonlinear models in ecotoxicology. Written by an international team of scientists, Ecotoxicology Modeling is of primary interest


Mechanistic Physiologically Based Pharmacokinetic (PBPK) Modeling of Renal and Systemic Disposition of Drugs and Metabolites

Physiologically-based pharmacokinetic (PBPK) models integrate system specific anatomy and physiology information with drug specific physicochemical and pharmacokinetic properties to predict drug disposition. Such integration permits items, events, processes, and pathways to communicate and influence each other interactively. By taking advantage of such mechanistic nature of PBPK modeling, drug dispositions under untested scenarios could be predicted by extrapolation from observed data in known conditions. Renal clearance is one of the major pathways governing drug dispositions, which has three main mechanisms: unbound


Quantitative Modeling in Toxicology

Quantitative Modeling in Toxicology
  • Author : Kannan Krishnan,Melvin E. Andersen
  • Publisher : John Wiley & Sons
  • Release : 01 April 2010
GET THIS BOOKQuantitative Modeling in Toxicology

Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions


Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Pharmacokinetic-Pharmacodynamic Modeling and Simulation
  • Author : Peter L. Bonate
  • Publisher : Springer Science & Business Media
  • Release : 14 May 2006
GET THIS BOOKPharmacokinetic-Pharmacodynamic Modeling and Simulation

A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops


Intracellular Delivery III

Intracellular Delivery III
  • Author : Aleš Prokop,Volkmar Weissig
  • Publisher : Springer
  • Release : 31 October 2016
GET THIS BOOKIntracellular Delivery III

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes


Human Biomonitoring for Environmental Chemicals

Human Biomonitoring for Environmental Chemicals
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
  • Publisher : National Academies Press
  • Release : 30 October 2006
GET THIS BOOKHuman Biomonitoring for Environmental Chemicals

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand


Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher : Academic Press
  • Release : 20 January 2021
GET THIS BOOKInhaled Medicines

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches