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Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans
  • Publsiher : Academic Press
  • Release : 22 August 2009
  • ISBN : 9780080922034
  • Pages : 630 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPhysiology and Pathology of Chloride Transporters and Channels in the Nervous System

Summary:
The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field


Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher : Academic Press
  • Release : 22 August 2009
GET THIS BOOKPhysiology and Pathology of Chloride Transporters and Channels in the Nervous System

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change


The olivo-cerebellar system

The olivo-cerebellar system
  • Author : Egidio D'Angelo,Elisa Galliano,Chris I De Zeeuw
  • Publisher : Frontiers Media SA
  • Release : 29 April 2016
GET THIS BOOKThe olivo-cerebellar system

During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well



Chloride Movements Across Cellular Membranes

Chloride Movements Across Cellular Membranes
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 22 September 2011
GET THIS BOOKChloride Movements Across Cellular Membranes

All living cells are surrounded by a lipidic membrane that isolates them from the often harsh environment. However, to take up nutrients, to excrete waste, and to communicate among each other, Nature has invented an incredibly diverse set of transmembrane transport proteins. Specialized transporters exist to shuttle electrically charged ions, positive cations like sodium or negative anions like chloride, across the membrane. In the recent years, tremendous progress has been made in the field of chloride transport. The present book


Physiology of Astroglia

Physiology of Astroglia
  • Author : Alexei Verkhratsky,Vladimir Parpura
  • Publisher : Biota Publishing
  • Release : 01 March 2015
GET THIS BOOKPhysiology of Astroglia

Astrocytes can be defined as the glia inhabiting the nervous system with the main function in the maintenance of nervous tissue homeostasis. Classified into several types according to their morphological appearance, many of astrocytes form a reticular structure known as astroglial syncytium, owing to their coupling via intercellular channels organized into gap junctions. Not only do astrocytes establish such homocellular contacts, but they also engage in intimate heterocellular interactions with neurons, most notably at synaptic sites. As synaptic structures house


Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
  • Author : Xin Tang
  • Publisher : Academic Press
  • Release : 01 June 2020
GET THIS BOOKNeuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease introduces core concepts and recent advances surrounding the physiology and pathophysiology of neuronal chloride transporters, with particular focus on the KCC and NKCC families of proteins. Chloride transporter biology is reviewed, including its role in setting the transmembrane chloride gradient and in chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters also address post-translational modifications and the trafficking of chloride transporters, protein interaction partners, and the genetic and environmental factors that regulate expression


GABA And Glutamate

GABA And Glutamate
  • Author : Janko Samardzic
  • Publisher : BoD – Books on Demand
  • Release : 21 March 2018
GET THIS BOOKGABA And Glutamate

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission,


Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 05 March 2021
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the



Evolutionary Physiology and Biochemistry

Evolutionary Physiology and Biochemistry
  • Author : Multiple authors
  • Publisher : BoD – Books on Demand
  • Release : 19 February 2018
GET THIS BOOKEvolutionary Physiology and Biochemistry

In 2016, it was 60 years since the eminent Soviet researcher, a disciple and a successor of Ivan Pavlov, Leon Orbeli had proclaimed the birth of a new branch of physiology, evolutionary physiology. In the same year, his ideas were embodied in the foundation in Leningrad, now Saint Petersburg, of the present Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences. This anniversary book includes the selected works carried out recently by his followers at the same institute.



Cell Physiology Source Book

Cell Physiology Source Book
  • Author : Nicholas Sperelakis
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKCell Physiology Source Book

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated -


Seldin and Giebisch's The Kidney

Seldin and Giebisch's The Kidney
  • Author : Robert J. Alpern,Steven C. Hebert
  • Publisher : Elsevier
  • Release : 10 October 2007
GET THIS BOOKSeldin and Giebisch's The Kidney

A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from


Ion Channels in Health and Sickness

Ion Channels in Health and Sickness
  • Author : Fatima Shad Kaneez
  • Publisher : BoD – Books on Demand
  • Release : 10 October 2018
GET THIS BOOKIon Channels in Health and Sickness

Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book


Epileptology

Epileptology
  • Author : Vladimir Kalinin
  • Publisher : BoD – Books on Demand
  • Release : 12 October 2016
GET THIS BOOKEpileptology

Epilepsy seems to represent one of the most frequent neurological diseases and occurs in about 1% of the general population. Although epilepsy is known since antiquity, the precise data on its pathogenesis and effective treatment are still collected and nowadays represents an interest for neurologists and psychiatrists. Being a neurological disease, epilepsy is characterized by a broad palette of comorbid psychiatric disorders (affective and anxiety disorders, psychoses) that reduce the quality of life. Moreover, the risk of suicidal attempts in persons