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Piperidine Based Drug Discovery

Piperidine Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publsiher : Elsevier
  • Release : 12 June 2017
  • ISBN : 0128134283
  • Pages : 358 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPiperidine Based Drug Discovery

Summary:
Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs


Piperidine-Based Drug Discovery

Piperidine-Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release : 12 June 2017
GET THIS BOOKPiperidine-Based Drug Discovery

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central


Fragment-based Drug Discovery

Fragment-based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 23 February 2016
GET THIS BOOKFragment-based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and


Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
  • Author : Robert Stroud,Janet Finer-Moore
  • Publisher : Royal Society of Chemistry
  • Release : 31 October 2007
GET THIS BOOKComputational and Structural Approaches to Drug Discovery

Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This


Carbohydrate-based Drug Discovery

Carbohydrate-based Drug Discovery
  • Author : Chi-Huey Wong
  • Publisher : Wiley-VCH
  • Release : 17 October 2003
GET THIS BOOKCarbohydrate-based Drug Discovery

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following:br” Chemical Synthesis of Carbohydratesbr” Carbohydrate Biosynthesis and Metabolism


Piperidine

Piperidine
  • Author : Mario Rubiralta,Ernest Giralt,Anna Diez
  • Publisher : Elsevier Science Limited
  • Release : 03 March 1991
GET THIS BOOKPiperidine

Piperidine, one of the simplest heterocyclic systems, is found in nature as part of several alkaloid compounds. Both natural and especially unnatural piperidine derivatives present interesting pharmacological properties. From a structural viewpoint, the conformation of piperidine has been the subject of one of the fiercest controversies in structural organic chemistry in the last few years. As a result of the combined use of several spectroscopic techniques, the conformational behavior of most types of piperidine-related compounds has been clarified. Some piperidine


Antiviral Drugs

Antiviral Drugs
  • Author : Wieslaw M. Kazmierski
  • Publisher : John Wiley & Sons
  • Release : 08 July 2011
GET THIS BOOKAntiviral Drugs

This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for


Synthesis of Best-Seller Drugs

Synthesis of Best-Seller Drugs
  • Author : Ruben Vardanyan,Victor Hruby
  • Publisher : Academic Press
  • Release : 07 January 2016
GET THIS BOOKSynthesis of Best-Seller Drugs

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work



Structure-based Design of Drugs and Other Bioactive Molecules

Structure-based Design of Drugs and Other Bioactive Molecules
  • Author : Arun K. Ghosh,Sandra Gemma
  • Publisher : John Wiley & Sons
  • Release : 11 August 2014
GET THIS BOOKStructure-based Design of Drugs and Other Bioactive Molecules

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use


Multicomponent Reactions

Multicomponent Reactions
  • Author : K.L. Ameta, Ph.D.,Anshu Dandia
  • Publisher : CRC Press
  • Release : 20 September 2017
GET THIS BOOKMulticomponent Reactions

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation


Fragment-based Approaches in Drug Discovery

Fragment-based Approaches in Drug Discovery
  • Author : Wolfgang Jahnke,Daniel A. Erlanson
  • Publisher : John Wiley & Sons
  • Release : 13 December 2006
GET THIS BOOKFragment-based Approaches in Drug Discovery

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous



Synthesis of Essential Drugs

Synthesis of Essential Drugs
  • Author : Ruben Vardanyan,Victor Hruby
  • Publisher : Elsevier
  • Release : 10 March 2006
GET THIS BOOKSynthesis of Essential Drugs

Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active


Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release : 27 March 2018
GET THIS BOOKPrivileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—