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Polycomb Group Proteins

Polycomb Group Proteins
  • Author : Vincenzo Pirrotta
  • Publsiher : Academic Press
  • Release : 01 January 2017
  • ISBN : 0128098228
  • Pages : 372 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPolycomb Group Proteins

Summary:
Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome


Polycomb Group Proteins

Polycomb Group Proteins
  • Author : Vincenzo Pirrotta
  • Publisher : Academic Press
  • Release : 01 January 2017
GET THIS BOOKPolycomb Group Proteins

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The


The Role of Polycomb Group Proteins in «Hox» Gene Regulation and Chromatin Organization

The Role of Polycomb Group Proteins in «Hox» Gene Regulation and Chromatin Organization
  • Author : Claudia Gentile
  • Publisher : Anonim
  • Release : 06 March 2021
GET THIS BOOKThe Role of Polycomb Group Proteins in «Hox» Gene Regulation and Chromatin Organization

"Proper embryonic development requires the function of the Hox gene family, which encode transcription factors essential for patterning the developing embryo along its main body axis. Most remarkably, the Hox genes are expressed in a spatially- and temporally- collinear fashion, corresponding to their relative positions along the chromosome. As such, mechanisms for Hox gene activation have been largely studied as the deregulation of Hox genes leads to severe developmental malformations. Our lab uses the developing limb as a model system



Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease
  • Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
  • Publisher : Springer
  • Release : 24 June 2016
GET THIS BOOKEtiology and Morphogenesis of Congenital Heart Disease

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide




Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
  • Author : Suming Huang,Michael D Litt,C. Ann Blakey
  • Publisher : Academic Press
  • Release : 19 October 2015
GET THIS BOOKEpigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a


Handbook of Epigenetics

Handbook of Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release : 10 July 2017
GET THIS BOOKHandbook of Epigenetics

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue


Puberty from Bench to Clinic

Puberty from Bench to Clinic
  • Author : J.-P. Bourguignon,A.-S. Parent
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 17 December 2015
GET THIS BOOKPuberty from Bench to Clinic

Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact


Arthropod Biology and Evolution

Arthropod Biology and Evolution
  • Author : Alessandro Minelli,Geoffrey Boxshall,Giuseppe Fusco
  • Publisher : Springer Science & Business Media
  • Release : 11 April 2013
GET THIS BOOKArthropod Biology and Evolution

More than two thirds of all living organisms described to date belong to the phylum Arthropoda. But their diversity, as measured in terms of species number, is also accompanied by an amazing disparity in terms of body form, developmental processes, and adaptations to every inhabitable place on Earth, from the deepest marine abysses to the earth surface and the air. The Arthropoda also include one of the most fashionable and extensively studied of all model organisms, the fruit-fly, whose name


Nuclear Mechanics and Genome Regulation

Nuclear Mechanics and Genome Regulation
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 12 October 2010
GET THIS BOOKNuclear Mechanics and Genome Regulation

In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields


Molecular Biology of Cancer

Molecular Biology of Cancer
  • Author : Lauren Pecorino
  • Publisher : Oxford University Press, USA
  • Release : 06 March 2021
GET THIS BOOKMolecular Biology of Cancer

"The most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear. -- Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an engaging and manageable route into the complex subject of cancer biology. Using the hallmarks of cancer as a foundation, the book describes the cellular and molecular mechanisms underpinning the transformation of healthy cells into cancer cells. -- after discussing a specific biological hallmark


Cancer Epigenetics

Cancer Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : CRC Press
  • Release : 19 September 2008
GET THIS BOOKCancer Epigenetics

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are