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Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records
  • Author : Cynthia J. Girman
  • Publsiher : Academic Press
  • Release : 01 April 2021
  • ISBN : 0128176644
  • Pages : 500 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKPragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records

Summary:
Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation and dissemination of pragmatic randomized trials. The book contains chapters encompassing common designs, along with the advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize such trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed. This comprehensive resource is valuable not only for biostatitians, but also for several members of biomedical field who are interested in applying pragmatic randomized clinical trials in their research. Brings typical designs and challenges of pragmatic randomized clinical trials (pRCTs) Encompasses analytic aspects for sample size determination of such trials Discusses real cases on operational challenges in launching and conducting pRCTs in electronic health records


Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records
  • Author : Cynthia J. Girman,Mary Elizabeth Ritchey
  • Publisher : Academic Press
  • Release : 01 April 2021
GET THIS BOOKPragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation and dissemination of pragmatic randomized trials. The book contains chapters encompassing common designs, along with the advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize such trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records


Clinical Trials

Clinical Trials
  • Author : Timothy M. Pawlik,Julie A. Sosa
  • Publisher : Springer Nature
  • Release : 10 March 2020
GET THIS BOOKClinical Trials

This extensively revised second edition is a unique and portable handbook focusing on clinical trials in surgery. It includes new educational materials addressing the rapid evolution of novel research methodologies in basic science, clinical and educational research. The underlying principles of clinical trials, trial design, the development of a study cohort, statistics, data safety, data monitoring, and trial publication for device and drug trials are also discussed. Clinical Trials provides a comprehensive resource on clinical trials in surgery and describes


Prevention Practice in Primary Care

Prevention Practice in Primary Care
  • Author : Sherri Sheinfeld Gorin
  • Publisher : Oxford University Press
  • Release : 01 November 2013
GET THIS BOOKPrevention Practice in Primary Care

Prevention Practice in Primary Care systematically explores state-of-the-art practical approaches to effective prevention in primary care. Guided by theory and evidence, the book reviews approaches to risk factor identification and modification for the major causes of mortality in adulthood, including cancer, stroke, and cardiovascular disease.


Pharmacoepidemiology

Pharmacoepidemiology
  • Author : Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
  • Publisher : John Wiley & Sons
  • Release : 23 October 2019
GET THIS BOOKPharmacoepidemiology

This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.


The Learning Healthcare System

The Learning Healthcare System
  • Author : Institute of Medicine,Roundtable on Evidence-Based Medicine
  • Publisher : National Academies Press
  • Release : 01 June 2007
GET THIS BOOKThe Learning Healthcare System

As our nation enters a new era of medical science that offers the real prospect of personalized health care, we will be confronted by an increasingly complex array of health care options and decisions. The Learning Healthcare System considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainable learning health care system that


Capturing Social and Behavioral Domains in Electronic Health Records

Capturing Social and Behavioral Domains in Electronic Health Records
  • Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Recommended Social and Behavioral Domains and Measures for Electronic Health Records
  • Publisher : National Academies Press
  • Release : 23 June 2014
GET THIS BOOKCapturing Social and Behavioral Domains in Electronic Health Records

Substantial empirical evidence of the contribution of social and behavioral factors to functional status and the onset and progression of disease has accumulated over the past few decades. Electronic health records (EHRs) provide crucial information to providers treating individual patients, to health systems, including public health officials, about the health of populations, and to researchers about the determinants of health and the effectiveness of treatment. Inclusion of social and behavioral health domains in EHRs is vital to all three uses.


Registries for Evaluating Patient Outcomes

Registries for Evaluating Patient Outcomes
  • Author : Agency for Healthcare Research and Quality/AHRQ
  • Publisher : Government Printing Office
  • Release : 01 April 2014
GET THIS BOOKRegistries for Evaluating Patient Outcomes

This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database


Examining the Impact of Real-World Evidence on Medical Product Development

Examining the Impact of Real-World Evidence on Medical Product Development
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release : 05 April 2019
GET THIS BOOKExamining the Impact of Real-World Evidence on Medical Product Development

Randomized controlled trials (RCTs) have traditionally served as the gold standard for generating evidence about medical interventions. However, RCTs have inherent limitations and may not reflect the use of medical products in the real world. Additionally, RCTs are expensive, time consuming, and cannot answer all questions about a product or intervention. Evidence generated from real-world use, such as real-world evidence (RWE) may provide valuable information, alongside RCTs, to inform medical product decision making. To explore the potential for using RWE


Clinical Research Computing

Clinical Research Computing
  • Author : Prakash Nadkarni
  • Publisher : Academic Press
  • Release : 29 April 2016
GET THIS BOOKClinical Research Computing

Clinical Research Computing: A Practitioner’s Handbook deals with the nuts-and-bolts of providing informatics and computing support for clinical research. The subjects that the practitioner must be aware of are not only technological and scientific, but also organizational and managerial. Therefore, the author offers case studies based on real life experiences in order to prepare the readers for the challenges they may face during their experiences either supporting clinical research or supporting electronic record systems. Clinical research computing is the


Best Care at Lower Cost

Best Care at Lower Cost
  • Author : Institute of Medicine,Committee on the Learning Health Care System in America
  • Publisher : National Academies Press
  • Release : 10 June 2013
GET THIS BOOKBest Care at Lower Cost

America's health care system has become too complex and costly to continue business as usual. Best Care at Lower Cost explains that inefficiencies, an overwhelming amount of data, and other economic and quality barriers hinder progress in improving health and threaten the nation's economic stability and global competitiveness. According to this report, the knowledge and tools exist to put the health system on the right course to achieve continuous improvement and better quality care at a lower cost. The costs


Secondary Analysis of Electronic Health Records

Secondary Analysis of Electronic Health Records
  • Author : MIT Critical Data
  • Publisher : Springer
  • Release : 09 September 2016
GET THIS BOOKSecondary Analysis of Electronic Health Records

This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on


Design and Analysis of Group-randomized Trials

Design and Analysis of Group-randomized Trials
  • Author : David M. Murray
  • Publisher : Oxford University Press, USA
  • Release : 08 March 1998
GET THIS BOOKDesign and Analysis of Group-randomized Trials

This text provides the most comprehensive treatment of the design and analytic issues involved in group-randomized trials. GRTs are comparative studies conducted to evaluate the effect of a health promotion intervention in which the units of assignment are identifiable groups (e.g., schools, worksites) and the units of observation are members of those groups (e.g., students, workers). The book reviews the underlying issues, the most widely used research designs, and analytic strategies. There is an emphasis on mixed-model regression,



Virtual Clinical Trials

Virtual Clinical Trials
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release : 16 November 2019
GET THIS BOOKVirtual Clinical Trials

Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies


Leadership Commitments to Improve Value in Health Care

Leadership Commitments to Improve Value in Health Care
  • Author : Institute of Medicine,Roundtable on Evidence-Based Medicine,J. Michael McGinnis,W. Alexander Goolsby,LeighAnne Olsen
  • Publisher : National Academies Press
  • Release : 27 August 2009
GET THIS BOOKLeadership Commitments to Improve Value in Health Care

This volume reports on discussions among multiple stakeholders about ways they might help transform health care in the United States. The U.S. healthcare system consists of a complex network of decentralized and loosely associated organizations, services, relationships, and participants. Each of the healthcare system's component sectors--patients, healthcare professionals, healthcare delivery organizations, healthcare product developers, clinical investigators and evaluators, regulators, insurers, employers and employees, and individuals involved in information technology--conducts activities that support a common goal: to improve patient health