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Prodrug Design

Prodrug Design
  • Author : Vivekkumar K Redasani,Sanjay B. Bari
  • Publisher : Academic Press
  • Release : 07 July 2015
GET THIS BOOKProdrug Design

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the

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Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery
  • Author : Jarkko Rautio
  • Publisher : John Wiley & Sons
  • Release : 11 January 2011
GET THIS BOOKProdrugs and Targeted Delivery

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

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Prodrugs Design

Prodrugs Design
  • Author : Rafik Karaman
  • Publisher : Nova Science Pub Incorporated
  • Release : 01 July 2014
GET THIS BOOKProdrugs Design

The prodrug approach is a promising and well established strategy for the development of new entities that possess superior efficacy, selectivity and reduced toxicity. Hence an optimized therapeutic outcome can be accomplished using this approach. Prodrug design is becoming more elaborate in the development of efficient and selective drug delivery systems. The targeted prodrug approach, in combination with gene delivery and controlled expression of enzymes and carrier proteins, is a promising strategy for precise and efficient drug delivery and enhancement

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Prodrugs

Prodrugs
  • Author : Valentino Stella,Ronald Borchardt,Michael Hageman,Reza Oliyai,Hans Maag,Jefferson Tilley
  • Publisher : Springer Science & Business Media
  • Release : 12 March 2007
GET THIS BOOKProdrugs

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

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Hydrolysis in Drug and Prodrug Metabolism

Hydrolysis in Drug and Prodrug Metabolism
  • Author : Bernard Testa,Joachim M. Mayer,Joachim Mayer
  • Publisher : John Wiley & Sons
  • Release : 01 August 2003
GET THIS BOOKHydrolysis in Drug and Prodrug Metabolism

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point

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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs
  • Author : Kamal Shah,Durgesh Nandini Chauhan,Nagendra Singh Chauhan,Pradeep Mishra
  • Publisher : CRC Press
  • Release : 13 May 2020
GET THIS BOOKRecent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews

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Textbook of Drug Design and Discovery

Textbook of Drug Design and Discovery
  • Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 07 October 2009
GET THIS BOOKTextbook of Drug Design and Discovery

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures an

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Textbook of Drug Design and Discovery, Third Edition

Textbook of Drug Design and Discovery, Third Edition
  • Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 25 July 2002
GET THIS BOOKTextbook of Drug Design and Discovery, Third Edition

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for

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Gibaldi's Drug Delivery Systems in Pharmaceutical Care

Gibaldi's Drug Delivery Systems in Pharmaceutical Care
  • Author : Mary Lee,Archana Desai
  • Publisher : ASHP
  • Release : 12 August 2022
GET THIS BOOKGibaldi's Drug Delivery Systems in Pharmaceutical Care

It is important to make therapeutics a critical component of teaching about dosage forms and to make dosage forms and drug delivery systems an integral part of therapeutics. This book will be the first to focus on the therapeutic impact of drug dosage forms.Tying together concepts of traditional pharmaceutics with therapeutics, Drug Delivery Systemsin Pharmaceutical Care demonstrates how the modern clinical pharmacist can integrate knowledge in pharmaceutical sciences and therapeutics with appreciation of patient needs and nuances to advise

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Computational Drug Design

Computational Drug Design
  • Author : D. C. Young
  • Publisher : John Wiley & Sons
  • Release : 28 January 2009
GET THIS BOOKComputational Drug Design

Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part

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Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 15 December 2006
GET THIS BOOKAnnual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market. Critical reviews

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Pharmacokinetic Optimization in Drug Research

Pharmacokinetic Optimization in Drug Research
  • Author : Bernard Testa,Han van de Waterbeemd,Gerd Folkers,Richard Guy
  • Publisher : John Wiley & Sons
  • Release : 26 March 2001
GET THIS BOOKPharmacokinetic Optimization in Drug Research

In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden

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Textbook of Drug Design and Discovery, Fifth Edition

Textbook of Drug Design and Discovery, Fifth Edition
  • Author : Kristian Stromgaard,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher : CRC Press
  • Release : 19 August 2016
GET THIS BOOKTextbook of Drug Design and Discovery, Fifth Edition

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover

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