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Prodrug Design

Prodrug Design
  • Author : Vivekkumar K Redasani,Sanjay B. Bari
  • Publisher : Academic Press
  • Release : 07 July 2015
GET THIS BOOKProdrug Design

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the

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Prodrugs Design

Prodrugs Design
  • Author : Rafik Karaman
  • Publisher : Nova Science Pub Incorporated
  • Release : 01 July 2014
GET THIS BOOKProdrugs Design

The prodrug approach is a promising and well established strategy for the development of new entities that possess superior efficacy, selectivity and reduced toxicity. Hence an optimized therapeutic outcome can be accomplished using this approach. Prodrug design is becoming more elaborate in the development of efficient and selective drug delivery systems. The targeted prodrug approach, in combination with gene delivery and controlled expression of enzymes and carrier proteins, is a promising strategy for precise and efficient drug delivery and enhancement

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Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery
  • Author : Jarkko Rautio
  • Publisher : John Wiley & Sons
  • Release : 11 January 2011
GET THIS BOOKProdrugs and Targeted Delivery

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

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Prodrug Designing of Nsaids

Prodrug Designing of Nsaids
  • Author : Smita Patil,Pramod Shirote,Rajendra Doijad
  • Publisher : LAP Lambert Academic Publishing
  • Release : 19 January 2022
GET THIS BOOKProdrug Designing of Nsaids

Separation of therapeutic effects from toxicity is a valuable goal in the drug development process. Prodrug design is a part of the general drug discovery process, in which a unique combination of therapeutically active substances is observed to have desirable pharmacological effects. In human therapy prodrug designing has given successful results in overcoming undesirable properties like absorption, nonspecificity, and poor bioavailability and GIT toxicity. Prodrug design is opening new doors in the challenging field of drug discovery, revolutionizing the art

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Prodrugs

Prodrugs
  • Author : Valentino Stella,Ronald Borchardt,Michael Hageman,Reza Oliyai,Hans Maag,Jefferson Tilley
  • Publisher : Springer Science & Business Media
  • Release : 12 March 2007
GET THIS BOOKProdrugs

These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs
  • Author : Kamal Shah,Durgesh Nandini Chauhan,Nagendra Singh Chauhan,Pradeep Mishra
  • Publisher : CRC Press
  • Release : 13 May 2020
GET THIS BOOKRecent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews

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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs
  • Author : Kamal Shah,Durgesh Nandini Chauhan,Nagendra Singh Chauhan,Pradeep Mishra
  • Publisher : CRC Press
  • Release : 13 May 2020
GET THIS BOOKRecent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews

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Hydrolysis in Drug and Prodrug Metabolism

Hydrolysis in Drug and Prodrug Metabolism
  • Author : Bernard Testa,Joachim M. Mayer,Joachim Mayer
  • Publisher : John Wiley & Sons
  • Release : 01 August 2003
GET THIS BOOKHydrolysis in Drug and Prodrug Metabolism

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point

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Enzyme Technologies

Enzyme Technologies
  • Author : Hsiu-Chiung Yang,Wu-Kuang Yeh,J. R. McCarthy
  • Publisher : John Wiley & Sons
  • Release : 22 November 2013
GET THIS BOOKEnzyme Technologies

Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with

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Development of Macromolecular Prodrug Conjugates for the Diagnosis and Treatment of Musculoskeletal Diseases

Macromolecular prodrug conjugate is a promising strategy for better diagnosis and treatment of musculoskeletal diseases. Our lab has pioneered this effort and has successfully developed multiple prodrug formulations. The general approach we have taken is to incorporate active ingredient (AI, including imaging probe or therapeutic agents) containing monomers into water-soluble and biocompatible polymers, such as N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymers. Structural parameters of these polymeric prodrugs, such as molecular weight (MW), drug loading, prodrug activation mechanism and the selection of

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