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Target Validation in Drug Discovery

Target Validation in Drug Discovery
  • Author : Brian W. Metcalf,Susan Dillon
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKTarget Validation in Drug Discovery

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and

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Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jürgen Moll,Sebastian Carotta
  • Publisher : Humana Press
  • Release : 12 April 2019
GET THIS BOOKTarget Identification and Validation in Drug Discovery

This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips

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Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 06 February 2014
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

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Target Discovery and Validation

Target Discovery and Validation
  • Author : Alleyn T. Plowright
  • Publisher : John Wiley & Sons
  • Release : 31 December 2019
GET THIS BOOKTarget Discovery and Validation

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling,

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Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jurgen Moll,Riccardo Colombo
  • Publisher : Humana Press
  • Release : 01 May 2016
GET THIS BOOKTarget Identification and Validation in Drug Discovery

This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."

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In Silico Technologies in Drug Target Identification and Validation

In Silico Technologies in Drug Target Identification and Validation
  • Author : Darryl Leon,Scott Markel
  • Publisher : CRC Press
  • Release : 13 June 2006
GET THIS BOOKIn Silico Technologies in Drug Target Identification and Validation

The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets. The book emphasizes computational tools,

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Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials
  • Author : Markus Rudin
  • Publisher : Springer Science & Business Media
  • Release : 11 July 2006
GET THIS BOOKImaging in Drug Discovery and Early Clinical Trials

This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.

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Target Discovery and Validation

Target Discovery and Validation
  • Author : Mouldy Sioud
  • Publisher : Springer Science & Business Media
  • Release : 08 December 2021
GET THIS BOOKTarget Discovery and Validation

Annotation These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.

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Phenotypic Drug Discovery

Phenotypic Drug Discovery
  • Author : Beverley Isherwood,Angelique Augustin
  • Publisher : Royal Society of Chemistry
  • Release : 10 December 2020
GET THIS BOOKPhenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and

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Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 21 November 2017
GET THIS BOOKPlatform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique

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Neurobiology of Huntington’s Disease

Neurobiology of Huntington’s Disease
  • Author : Donald C. Lo,Robert E. Hughes
  • Publisher : CRC Press
  • Release : 02 July 2010
GET THIS BOOKNeurobiology of Huntington’s Disease

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding

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Target Discovery and Validation Reviews and Protocols

Target Discovery and Validation Reviews and Protocols
  • Author : Mouldy Sioud
  • Publisher : Humana Press
  • Release : 28 October 2010
GET THIS BOOKTarget Discovery and Validation Reviews and Protocols

Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined

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Protein Degradation with New Chemical Modalities

Protein Degradation with New Chemical Modalities
  • Author : Hilmar Weinmann,Craig Crews
  • Publisher : Royal Society of Chemistry
  • Release : 07 October 2020
GET THIS BOOKProtein Degradation with New Chemical Modalities

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in

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