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Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi
  • Publsiher : Academic Press
  • Release : 20 May 2016
  • ISBN : 0128018038
  • Pages : 224 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKThresholds of Genotoxic Carcinogens

Summary:
Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation


Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi,Shoji Fukushima
  • Publisher : Academic Press
  • Release : 20 May 2016
GET THIS BOOKThresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold

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The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult
  • Author : Helmut Greim,Richard Albertini
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOKThe Cellular Response to the Genotoxic Insult

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens,

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Genotoxic Impurities

Genotoxic Impurities
  • Author : Andrew Teasdale
  • Publisher : John Wiley & Sons
  • Release : 29 March 2011
GET THIS BOOKGenotoxic Impurities

This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and

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Cancer Risk Assessment

Cancer Risk Assessment
  • Author : Ching-Hung Hsu,Todd Stedeford
  • Publisher : John Wiley & Sons
  • Release : 08 December 2010
GET THIS BOOKCancer Risk Assessment

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and

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Mutagenic Impurities

Mutagenic Impurities
  • Author : Andrew Teasdale
  • Publisher : John Wiley & Sons
  • Release : 02 March 2022
GET THIS BOOKMutagenic Impurities

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers

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Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release : 16 May 2020
GET THIS BOOKInformation Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

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Hayes' Principles and Methods of Toxicology, Sixth Edition

Hayes' Principles and Methods of Toxicology, Sixth Edition
  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release : 10 October 2014
GET THIS BOOKHayes' Principles and Methods of Toxicology, Sixth Edition

Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms

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Validation of Alternative Methods for Toxicity Testing

Validation of Alternative Methods for Toxicity Testing
  • Author : Chantra Eskes,Maurice Whelan
  • Publisher : Springer
  • Release : 26 September 2016
GET THIS BOOKValidation of Alternative Methods for Toxicity Testing

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are

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Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release : 31 August 2001
GET THIS BOOKGenetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and

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Science and Decisions

Science and Decisions
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
  • Publisher : National Academies Press
  • Release : 24 March 2009
GET THIS BOOKScience and Decisions

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment

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Practical Toxicology

Practical Toxicology
  • Author : David Woolley,Adam Woolley
  • Publisher : CRC Press
  • Release : 16 March 2017
GET THIS BOOKPractical Toxicology

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the

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Quantitative Risk Assessment for Environmental and Occupational Health

Quantitative Risk Assessment for Environmental and Occupational Health
  • Author : William H. Hallenbeck
  • Publisher : CRC Press
  • Release : 09 June 1993
GET THIS BOOKQuantitative Risk Assessment for Environmental and Occupational Health

Quantitative Risk Assessment for Environmental and Occupational Health, Second Edition features twice as many risk analysis models with complete examples as the previous edition. The book features new information in the following areas: Calculation of human dose rate and dose from experimental studies (animal and human) Quantitation of response Tests of significance Calculation of excess risk Calculation of confidence limits on excess risk Individual and group excess risk Conversion of risk factor units Acceptable concentrations Quantitative Risk Assessment for Environmental

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A Guide to Practical Toxicology

A Guide to Practical Toxicology
  • Author : David Woolley,Adam Woolley
  • Publisher : CRC Press
  • Release : 20 February 2003
GET THIS BOOKA Guide to Practical Toxicology

Toxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice. This lucid, readable book encourages both experienced toxicologists and those in training to place toxicological investigation in such a framework. It looks at the importance of

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Low Dose Exposures in the Environment

Low Dose Exposures in the Environment
  • Author : C. Streffer,H. Bolt,D. Follesdal,P. Hall,J.G. Hengstler,P. Jacob,D Oughton,K. Prieß,E. Rehbinder,E. Swaton
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKLow Dose Exposures in the Environment

The ever-increasing release of harmful agents due to human activities have led in some areas of the world to heavy pollution. In order to protect human health and the environment, environmental standards that shall limit the release and the concentration of those toxic agents in the environment and hence the exposure to it have to be established. The related assessment and decision-making procedures have to be based on solid scientific data about the effects and mechanisms of these agents as

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