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Toxicogenomics Based Cellular Models

Toxicogenomics Based Cellular Models
  • Author : Jos Kleinjans
  • Publsiher : Anonim
  • Release : 29 January 2014
  • ISBN : 9780123978622
  • Pages : 362 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKToxicogenomics Based Cellular Models

Summary:
Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores 'omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays Includes an overview of current testing methods and risk assessment frameworks Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward


Toxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models
  • Author : Jos Kleinjans
  • Publisher : Anonim
  • Release : 29 January 2014
GET THIS BOOKToxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well

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Toxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models
  • Author : Jos Kleinjans
  • Publisher : Academic Press
  • Release : 02 January 2014
GET THIS BOOKToxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well

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Toxicogenomics in Predictive Carcinogenicity

Toxicogenomics in Predictive Carcinogenicity
  • Author : Michael D. Waters,Russell S. Thomas
  • Publisher : Royal Society of Chemistry
  • Release : 10 June 2016
GET THIS BOOKToxicogenomics in Predictive Carcinogenicity

Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.

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Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release : 16 May 2020
GET THIS BOOKInformation Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

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Big Data in Predictive Toxicology

Big Data in Predictive Toxicology
  • Author : Andrea-Nicole Richarz,Daniel Neagu
  • Publisher : Royal Society of Chemistry
  • Release : 10 December 2019
GET THIS BOOKBig Data in Predictive Toxicology

The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses

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Translating Diverse Environmental Data into Reliable Information

Translating Diverse Environmental Data into Reliable Information
  • Author : Daniel Vallero
  • Publisher : Academic Press
  • Release : 15 September 2017
GET THIS BOOKTranslating Diverse Environmental Data into Reliable Information

Translating Diverse Environmental Data into Reliable Information: How to Coordinate Evidence from Different Sources is a resource for building environmental knowledge, particularly in the era of Big Data. Environmental scientists, engineers, educators and students will find it essential to determine data needs, assess their quality, and efficiently manage their findings. Decision makers can explore new open access databases and tools, especially portals and dashboards. The book demonstrates how environmental knowledgebases are and can be built to meet the needs of

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Advances in Molecular Toxicology

Advances in Molecular Toxicology
  • Author : James C. Fishbein,Jacqueline M. Heilman
  • Publisher : Academic Press
  • Release : 21 September 2018
GET THIS BOOKAdvances in Molecular Toxicology

Advances in Molecular Toxicology, Volume Twelve, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The

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Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences

Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences
  • Author : Pierre R. Bushel,Weida Tong
  • Publisher : Frontiers Media SA
  • Release : 09 April 2019
GET THIS BOOKIntegrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences

Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results )

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Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures
  • Author : Gunnar F. Nordberg,Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 21 August 2018
GET THIS BOOKRisk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods

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Toxicoepigenetics

Toxicoepigenetics
  • Author : Shaun D. McCullough,Dana Dolinoy
  • Publisher : Academic Press
  • Release : 02 November 2018
GET THIS BOOKToxicoepigenetics

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
  • Publisher : National Academies Press
  • Release : 19 November 2007
GET THIS BOOKApplications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort

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Using 21st Century Science to Improve Risk-Related Evaluations

Using 21st Century Science to Improve Risk-Related Evaluations
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Incorporating 21st Century Science into Risk-Based Evaluations
  • Publisher : National Academies Press
  • Release : 16 February 2017
GET THIS BOOKUsing 21st Century Science to Improve Risk-Related Evaluations

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating

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Emerging Bioinformatic Tools in Toxicogenomics

Emerging Bioinformatic Tools in Toxicogenomics
  • Author : Danyel Jennen,Paul Jennings
  • Publisher : Frontiers Media SA
  • Release : 27 February 2020
GET THIS BOOKEmerging Bioinformatic Tools in Toxicogenomics

Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches

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Cellular and Molecular Toxicology of Nanoparticles

Cellular and Molecular Toxicology of Nanoparticles
  • Author : Quaiser Saquib,Mohammad Faisal,Abdulaziz A. Al-Khedhairy,Abdulrahman A. Alatar
  • Publisher : Springer
  • Release : 16 February 2018
GET THIS BOOKCellular and Molecular Toxicology of Nanoparticles

This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration,

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Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense

Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures
  • Publisher : National Academies Press
  • Release : 01 September 2015
GET THIS BOOKApplication of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense

The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National

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