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Translational Systems Biology

Translational Systems Biology
  • Author : Yoram Vodovotz
  • Publsiher : Elsevier
  • Release : 08 October 2014
  • ISBN : 0123978904
  • Pages : 178 pages
  • Rating : 4/5 from 21 ratings
GET THIS BOOKTranslational Systems Biology

Summary:
Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams


Translational Systems Biology

Translational Systems Biology
  • Author : Yoram Vodovotz,Gary An
  • Publisher : Elsevier
  • Release : 08 October 2014
GET THIS BOOKTranslational Systems Biology

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the


Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine
  • Author : Qing Yan
  • Publisher : Academic Press
  • Release : 18 April 2017
GET THIS BOOKTranslational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics,


Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOKTranslational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease



Handbook of Systems Biology

Handbook of Systems Biology
  • Author : Marian Walhout,Marc Vidal,Job Dekker
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKHandbook of Systems Biology

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as


Translational Biotechnology

Translational Biotechnology
  • Author : Yasha Hasija
  • Publisher : Academic Press
  • Release : 17 January 2021
GET THIS BOOKTranslational Biotechnology

Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This


Translational Biology in Medicine

Translational Biology in Medicine
  • Author : Monty Montano
  • Publisher : Woodhead Pub Limited
  • Release : 15 August 2014
GET THIS BOOKTranslational Biology in Medicine

The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods


Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
  • Author : David B. Teplow
  • Publisher : Academic Press
  • Release : 16 October 2018
GET THIS BOOKProgress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and


Systems Biology

Systems Biology
  • Author : Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski
  • Publisher : Anonim
  • Release : 14 April 2021
GET THIS BOOKSystems Biology

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi


Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOKTranslational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease


Systems Biology of Microbial Infection

Systems Biology of Microbial Infection
  • Author : Reinhard Guthke,Jörg Linde,Marc Thilo Figge,Franziska Mech
  • Publisher : Frontiers E-books
  • Release : 14 April 2021
GET THIS BOOKSystems Biology of Microbial Infection

The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data


Encyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 21 August 2018
GET THIS BOOKEncyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for


Translational Bioinformatics and Its Application

Translational Bioinformatics and Its Application
  • Author : Dong-Qing Wei,Yilong Ma,William C.S. Cho,Qin Xu,Fengfeng Zhou
  • Publisher : Springer
  • Release : 31 March 2017
GET THIS BOOKTranslational Bioinformatics and Its Application

This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy


A Systems Biology Approach to Blood

A Systems Biology Approach to Blood
  • Author : Seth Joel Corey,Marek Kimmel,Joshua N. Leonard
  • Publisher : Springer
  • Release : 06 December 2014
GET THIS BOOKA Systems Biology Approach to Blood

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems